Elucidating the Basic Principles of Macromolecular & Supramolecular Structure
Using alpha-lytic protease, we have pursued the mechanisms of enzyme specificity and explored fundamental concepts of protein stability and folding. This understanding is now being applied to the problem of nuclear receptor signaling.
In parallel, we have made significant progress in analyzing the structure of centrosomes and chromosomes.
Throughout, we have pioneered the development of new methods for determining structure at both the cellular and molecular levels.
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Latest Publications
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Mesophile versus Thermophile: Insights Into the Structural Mechanisms of Kinetic Stability
Brian A. Kelch and David A. Agard |
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AIDA: an adaptive image deconvolution algorithm with application to multi-frame and three-dimensional data.
Hom EF, Marchis F, Lee TK, Haase S, Agard DA, Sedat JW |
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