Elucidating the Basic Principles of Macromolecular & Supramolecular Structure
Using alpha-lytic protease, we have pursued the mechanisms of enzyme specificity and explored fundamental concepts of protein stability and folding. This understanding is now being applied to the problem of nuclear receptor signaling.
In parallel, we have made significant progress in analyzing the structure of centrosomes and chromosomes.
Throughout, we have pioneered the development of new methods for determining structure at both the cellular and molecular levels.
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Latest Publications
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pH-Dependent Conformational Changes in Bacterial Hsp90 Reveal a Grp94-Like Conformation at pH 6 That Is Highly Active in Suppression of Citrate Synthase Aggregation
Krukenberg KA, Southworth DR, Street TO, Agard DA |
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Fully automated, sequential tilt-series acquisition with Leginon.
Suloway C, Shi J, Cheng A, Pulokas J, Carragher B, Potter CS, Zheng SQ, Agard DA, Jensen GJ |
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