25 Articles citing this article:

Jarmula, Adam; Dowiercial, Anna; Rode, Wojciech. A molecular modeling study of the interaction of 2'-fluoro-substituted analogues of dUMP/FdUMP with thymidylate synthase. Bioorganic & Medicinal Chemistry Letters (2008), 18(8), 2701-2708.

Gibson, Lydia M.; Lovelace, Leslie L.; Lebioda, Lukasz. The R163K mutant of human thymidylate synthase is stabilized in an active conformation: Structural asymmetry and reactivity of cysteine 195. Biochemistry

Ciobanu, Luisa; Sweedler, Jonathan V.; Webb, Andrew G. Microcoil NMR for reaction monitoring. NMR Imaging in Chemical Engineering (2006), 123-139.

Abraham, D. J. Structure-based drug design - a historical perspective and the future. Comprehensive Medicinal Chemistry II (2006), 4, 65-86.

Lovelace, Leslie L.; Gibson, Lydia M.; Lebioda, Lukasz. Cooperative Inhibition of Human Thymidylate Synthase by Mixtures of Active Site Binding and Allosteric Inhibitors. Biochemistry (2007), 46(10), 2823-2830.

Costi, M. Paola; Gelain, Arianna; Barlocco, Daniela; Ghelli, Stefano; Soragni, Fabrizia; Reniero, Fabiano; Rossi, Tiziana; Ruberto, Antonio; Guillou, Claude; Cavazzuti, Antonio; Casolari, Chiara; Ferrari, Stefania. Antibacterial Agent Discovery Using Thymidylate Synthase Biolibrary Screening. Journal of Medicinal Chemistry (2006), 49(20), 5958-5968.

Sotelo-Mundo, Rogerio R.; Changchien, Liming; Maley, Frank; Montfort, William R. Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity. Journal of Biochemical and Molecular Toxicology (2006), 20(2), 88-92.

Finer-Moore, Janet S.; Anderson, Amy C.; O'Neil, Robert H.; Costi, M. Paola; Ferrari, Stefania; Krucinski, Jolanta; Stroud, Robert M. The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallographica, Section D: Biological Crystallography (2005), D61(10), 1320-1334.

Costi, M. P.; Ferrari, S.; Venturelli, A.; Calo, S.; Tondi, D.; Barlocco, D. Thymidylate synthase structure, function and implication in drug discovery. Current Medicinal Chemistry (2005), 12(19), 2241-2258.

Lovelace, Leslie L.; Minor, Wladek; Lebioda, Lukasz. Structure of human thymidylate synthase under low-salt conditions. Acta Crystallographica, Section D: Biological Crystallography (2005), D61(5), 622-627.

Gmeiner, W. H. Novel chemical strategies for thymidylate synthase inhibition. Current Medicinal Chemistry (2005), 12(2), 191-202.

Forsthoefel, Antonia M.; Pena, Maria Marjorette O.; Xing, Yang Yang; Rafique, Zubaid; Berger, Franklin G. Structural Determinants for the Intracellular Degradation of Human Thymidylate Synthase. Biochemistry (2004), 43(7), 1972-1979.

Berger, Sondra H.; Berger, Franklin G.; Lebioda, Lukasz. Effects of ligand binding and conformational switching on intracellular stability of human thymidylate synthase. Biochimica et Biophysica Acta (2004), 1696(1), 15-22.

Ferrari, Stefania; Costi, Paola M.; Wade, Rebecca C. Inhibitor Specificity via Protein Dynamics Insights from the Design of Antibacterial Agents Targeted Against Thymidylate Synthase. Chemistry & Biology (2003), 10(12), 1183-1193.

O'Neil, Robert H.; Lilien, Ryan H.; Donald, Bruce R.; Stroud, Robert M.; Anderson, Amy C. Phylogenetic Classification of Protozoa Based on the Structure of the Linker Domain in the Bifunctional Enzyme, Dihydrofolate Reductase-Thymidylate Synthase. Journal of Biological Chemistry (2003), 278(52), 52980-52987.

Ciobanu, Luisa; Jayawickrama, Dimuthu A.; Zhang, Xiaozhong; Webb, Andrew G.; Sweedler, Jonathan V. Measuring reaction kinetics by using multiple microcoil NMR spectroscopy. Angewandte Chemie, International Edition (2003), 42(38), 4669-4672, S4669/1-S4669/2.

Lin, Xiukun; Liu, Jun; Maley, Frank; Chu, Edward. Role of cysteine amino acid residues on the RNA binding activity of human thymidylate synthase. Nucleic Acids Research (2003), 31(16), 4882-4887.

D. Gonzalez-Pacanowska, L. M. Ruiz-Perez, M. A. Carreras-Gomez, M. P. Costi, R. M. Stroud, J. Finer-Moore, and D. V. Santi. The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase. Protein Eng., August 1, 2003; 16(8): 607 - 614.

Saxl, Ruth L.; Reston, James; Nie, Zhe; Kalman, Thomas I.; Maley, Frank. Modification of Escherichia coli Thymidylate Synthase at Tyrosine-94 by 5-Imidazolylpropynyl-2'-deoxyuridine 5'-Monophosphate. Biochemistry (2003), 42(15), 4544-4551.

D. L. Birdsall, J. Finer-Moore, and R. M. Stroud. The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity. Protein Eng., March 1, 2003; 16(3): 229 - 240.

Stroud, Robert M.; Finer-Moore, Janet S. Conformational Dynamics along an Enzymatic Reaction Pathway: Thymidylate Synthase, "the Movie". Biochemistry (2003), 42(2), 239-247.

Finer-Moore, Janet S.; Santi, Daniel V.; Stroud, Robert M. Lessons and Conclusions from Dissecting the Mechanism of a Bisubstrate Enzyme: Thymidylate Synthase Mutagenesis, Function, and Structure. Biochemistry (2003), 42(2), 248-256.

Kawate, Hisaya; Landis, Daniel M.; Loeb, Lawrence A. Distribution of Mutations in Human Thymidylate Synthase Yielding Resistance to 5-Fluorodeoxyuridine. Journal of Biological Chemistry (2002), 277(39), 36304-36311.

Sayre, P. H.; Finer-Moore, J. S.; Fritz, T. A.; Biermann, D.; Gates, S. B.; MacKellar, W. C.; Patel, V. F.; Stroud, R. M. Addendum. Journal of Molecular Biology (2002), 316(4), 1005.

Peaslee, Kimberly A. W.; Anderson, Amy C. Toward rational design of species-specific inhibitors of Pneumocystis carinii thymidylate synthase and Toxoplasma gondii dihydrofolate reductase-thymidylate synthase. Journal of Eukaryotic Microbiology (2001), (Suppl.), 174S-175S.