Michelle Lovett

My goal is to set up a phage display system in the laboratory, with the first target being to engineer scFv molecules against components of the g-TuRC complex, to further enable us to study their function in microtubule nucleation.

Previously, after receiving a B.A. in Biology from the University of California at Berkeley, I worked for one year in biotech, then 12 years at UCSF in two different laboratories. In the Welch Lab I studied the role of heat shock (or "stress") proteins in the normal and metabolically stressed cell, with the focus on hsp70 in determining its function as a molecular chaperone. In the GI Lab I studied two families of signaling molecules (neuropeptides and proteases) and their G-protein coupled receptors, to determine the role of these mediators and receptors in inflammation and repair in the gastrointestinal tract.

Publications

McConalogue K*, Déry O*, Lovett M, Wong H, Walsh J, Grady EF, Bunnett NW: Substance P-induced trafficking of ß-arrestins: the role of ß-arrestins in endocytosis of the neurokinin-1 receptor. J Biol Chem, 274, 16257-68, 1999.
(* = equal contribution)

Ricciardolo FL, Lovett M, Halliday DA, Nadel JA, Kaneko T, Bunnett NW, Geppetti P: Bradykinin increases intracellular calcium levels in a human bronchial epithelial cell line via the B2 receptor subtype. Inflammation Research, 47, 231-235, 1998.

Garland AM, Grady EF, Lovett M, Vigna SR, Frucht MM, Krause JE, Bunnett NW: Mechanisms of desensitization and resensitization of G protein-coupled neurokinin-1 and neurokinin-2 receptors. Molec Pharmacol 49, 438-446, 1996.

Grady EF, Garland AM, Gamp PD, Lovett M, Payan DG, Bunnett NW: Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Molec Biol Cell, 6, 509-524, 1995.

Okamoto A, Lovett M, Payan DG, Bunnett NW: Interaction between neutral endopeptidase (EC 3.4.24.11) and the substance P (NK-1) receptor expressed in mammalian cells. Biochem J 299, 683-693, 1994.

Beckmann RP, Lovett M, Welch WJ: Examining the function and regulation of hsp70 in cells subjected to metabolic stress. J Cell Biol 117(6), 1137-1150, 1992.