Shawn Zheng

bioinformatics specialist

Department of Biochemistry & Biophysics
University of California, San Francisco
Mission Bay, Genentech Hall
600 16th St.
San Francisco CA
94143-2240

I am responsible for the development of electron tomography system. This system provides an automated means to view three dimensional biological structures from two dimensional tilt series acquired on electron microscopes using CCD cameras.

I obtained my doctoral degree in 1999 at the University of Utah. My dessertation is regarding the vortical structures generated by the interaction of trsnsverse jets in crossflows. Those structures hold extensive applications in many areas such as chemical mixing and microchannel cooling. An image based experimental technique was employed to view the vortical structures and to extract quantitative information of those structures.

Publications:

Zheng SQ, Kollman JM, Braunfeld MB, Sedat JW, Agard DA, "Automated acquisition of electron microscopic random conical tilt sets," J Struct Biol. 2007 Jan;157(1):148-55.161.(html or pdf).

Zheng SQ, Keszthelyi B, Branlund E, Lyle JM, Braunfeld MB, Sedat JW, and Agard DA,"UCSF tomography: An integrated software suite for real-time electron microscopic tomographic data collection, alignment, and reconstruction," J Struct Biol. 2006 Jun 23 (html or pdf).

Zheng, Q.S., Braunfeld, M.B., Sedat, J.W, and Agard, DA. "An improved strategy for automated electron microscopic tomography," J. Struct. Biol., (2004) 147(2):91-101 (html or pdf).