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Hsp90 structure, mechanism,and homeostasis
microtubule nucleation/centrosome structure
bacteriophage cell biology
advanced microscopies

We focus on three fundamental areas in mechanistic cell biology and structural problems of translational import:

1) Hsp90 molecular chaperone-assisted protein folding, activation and homeostasis

2) The mechanism of microtubule nucleation, centrosome structure and assembly

3) The role of newly discovered bacteriophage cytoskeleton and phage nucleus

4) Application of cryoEM to structures of key complexes of translational interest

Our strategy is to use and develop a broad array of methods to tackle otherwise intractable problems in vitro, allowing us to gain unique and significant molecular insights. We also continue significant technological advances - the most revolutionary being our aiding the development of the game-changing single-electron counting cryoEM camera and most recently, developing greatly improved software for correcting beam-induced motion.

hsp90:Cdc37:Cdk4 structure

600 16th St, San Francisco, California, 94143-2240 | phone (415)476-2521 | fax (415) 476-1902

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