Ed Pate

Position:      Visiting Professor, Washington State U.
Specialty:    Biophysics, Mathematics, Physiology,
                     Electron Paramagnetic Resonance
Phone:         (415) 476-1975
Fax:             (415) 476-1902
Email:          edpate@hotmail.com

Research Interests:
- Mathematical Modeling of the Cross-Bridge Cycle
    - Conformational changes in myosin, kinesin and ncd

Selected Publications:

  • Closing of the nucleotide pocket of kinesin-family motors upon binding to microtubules.
    Naber, N., Minehardt, T.J., Rice, S., Chen, X., Grammer, J., Matuska, M., Vale, R.D., Kollman, P.A., Car, R., Yount. R.G., Cooke, R., Pate, E. Science, 300 (5620): 798-801 (2003).
  • EPR Spectroscopy Shows a Microtubule-Dependent Conformational Change in the Kinesin Switch 1 Domain.
    Naber, N., Rice S., Matuska, M., Vale, R.D., Cooke, R., Pate, E. Biophysical Journal, 84 (5): 3190-3196 (2003).
  • A novel restricted photoaffinity spin-labeled non-nucleoside ATP analogue as a covalently attached reporter group of the active site of Myosin subfragment 1.
    Chen, X., Grammer, J., Lawson, J.D., Cooke, R., Pate, E., Yount, R.G.Biochemistry 26;41(8):2609-2620 (2002).
  • A classical and ab initio study of the interaction of the myosin triphosphate binding domain with ATP.
    Minehardt, T. J., N. Marzari, R. Cooke, E. Pate, P. A. Kollman, and R. Car. Biophysical Journal, 82:660-675. (2002).
  • Molecular dynamics study of the energetic, mechanistic, and structural implications of a closed phosphate tube in ncd.
    Minehardt, T.J., Cooke, R., Pate, E., Kollman, P.A.
    Biophysical Journal, 80(3):1151-68, (2001).
  • A Structural Change in the Kinesin Motor Protein that Drives Motility.
    Rice, S., A. W. Lin, D. Safer, C. L. Hart, N. Naber, B. O. Carragher, S. M. Cain, E. Pechatnikova, E. M. Wilson-Kubalek, M. Whittaker, E. Pate, R. Cooke, E. W. Taylor, R. A. Milligan, and R. D. Vale. Nature 402:778-784 (1999).
  • Binding of ncd to Microtubules Induces a Conformational Change Near the Junction of the Motor Domain with the Neck
    Naber, N., Cooke, R., Pate, E.
    Biochemistry  36:  9681 - 9689  (1997)
  • Opening of the Myosin Nucleotide Triphosphate Binding Domain During the ATPase Cycle, Pate, E., Naber, N., Matuska, M., Franks-Skiba, K. and Cooke, R., Biochemistry  36:  (1997)
  • Wilson, C., Naber, N. Pate, E., Cooke, R. The Myosin Inhibitor Blebbistatin Stabilizes The Super-Relaxed State In Skeletal Muscle, Biophys J. 107:1637-46. (2014) PMID:25296316
  • Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R. Spectroscopic Studies of the Super Relaxed State of Skeletal Muscle. PLoS One. 2016 Aug 1;11(8):e0160100. doi: 10.1371/journal.pone.0160100 PMID:27479128
  • Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R. Piperine’s mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle. Proc Natl Acad Sci USA, in press.



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