Nariman Naber Ph.D.

Position:     Research Scientist
Research Interests :   Structural and energetic studies of motor proteins using biophysical and biochemical techniques, synthatic organic chemistry
Phone:        (415) 476-1975
Fax:             (415) 476-1902

Selected Publications:

    1. Rice, S., Lin, A.W., Safer, D., Hart, C.L., Naber, N., Carragher, B.O., Cain, S.M., Pechatnikova, E., Wilson-Kubalek, E.M., Whittaker, M., Pate, E., Cooke, R., Taylor, E.W., Milligan, R.A., an Vale, R.D. A Structural Change in the Kinesin Motor Protein that Drives Motility. Nature 402:778-784 (1999).

    2. Rice, S., Cui, Y., Sindelar, C., Naber, N., Matuska, M., Vale, R., Cooke, R. Thermodynamic Properties of the Kinesin Neck Region Docking to the Catalytic Core Biophysical Journal, 84:1844-1854 (2003).

    3. Naber, N., Rice, S., Matuska, M., Vale, R.D., Pate, E., and Cooke, R. EPR spectroscopy shows a microtubule-dependent conformational change in the switch 1 domain of kinesin. Biophysical J. 84:3190-3196 (2003).

    4. Naber, N., Minehardt, T.J., Rice, S., Chen, X., Grammer, J., Matuska, M., Car, R., Vale, R.D., Kollman, P.A., Yount, R.G., Cooke, R., and Pate, E.. The nucleotide pocket of kinesin-family motors closes upon binding to microtubules Science 300:798-801 (2003).

    5. Naber, N. , Purcell, T., Pate, E., and Cooke, R. Dynamics Of The Nucleotide Pocket Of Myosin Measured By Spin-Labeled Nucleotides. Biophys. J. 92:172-184 (2007). PMID: 17028139

    6. Naber, N., Cooke, R., and Pate, E. Slow Myosin ATP Turnover In The Super-Relaxed State In Tarantula Muscle. J. Mol. Biol. 411:943-950 (2011) PMID: 21763701

    7. Racki, L. R. , Naber, N. Pate, E. Leonard, J. Cooke, R., Narlikar, G. J. The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme. J Mol Biol. 426:2034-44. (2014) PMID:24607692

    8. Wilson, C., Naber, N. Pate, E., Cooke, R. The Myosin Inhibitor Blebbistatin Stabilizes The Super-Relaxed State In Skeletal Muscle, Biophys J. 107:1637-46. (2014) PMID:25296316

    9. Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R. Spectroscopic Studies of the Super Relaxed State of Skeletal Muscle. PLoS One. 2016 Aug 1;11(8):e0160100. doi: 10.1371/journal.pone.0160100 PMID:27479128

    10. Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R. Piperine’s mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle. Proc Natl Acad Sci USA, in press.


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