Nariman Naber Ph.D.

Position:     Research Scientist
Research Interests :   Structural and energetic studies of motor proteins using biophysical and biochemical techniques, synthatic organic chemistry
Phone:        (415) 476-1975
Fax:             (415) 476-1902
Email:          Nariman.Naber@UCSF.edu

Selected Publications:

1. Rice, S., Lin, A.W., Safer, D., Hart, C.L., Naber, N., Carragher, B.O., Cain, S.M., Pechatnikova, E., Wilson-Kubalek,E.M., Whittaker, M., Pate, E., Cooke, R., Taylor, E.W., Milligan, R.A., and Vale, R.D. A Structural Change in the Kinesin Motor Protein that Drives Motility. Nature 402:778-784 (1999)
2. Kurt S. Thorn, Nariman Naber, Marija Matuska, Ronald D. Vale and Roger Cooke, “A Novel Method of Affinity-Purifying Proteins Using a Bis-Arsenical Flourescein”. Protein Science, 9, 213-217 (2000).
3. Charles V. Sindelar, Mary Jane Bundy, Sarah Rice, Nariman Naber, Robert Fletterick and Roger Cooke, “Two Conformations in the Human Kinesin Power Stroke Defined by X-ray Crystallography and EPR Spectroscopy”. Nature Structural Biology, 9, 844-848 (2002).
4. Sarah E. Rice, Yujia Cui, Charles V. Sindelar, Nariman Naber, Marija Matuska, Ron D. Vale, and Roger Cooke. “Thermodynamic Properties of the Kinesin Neck Region Docking to the Catalytic Core”. Biophys. J., 84, 1844-1854 (2003).
5. Nariman I. Naber, Sarah Rice, Marija Matuska, Ronald D. Vale, Roger Cooke, and Edward F. Pate, “EPR Spectroscopy Shows a Microtubule-Dependent Conformational Change in the Kinesin Switch 1 Domain”. Biophys. J., 84, 3190-3196 (2003).
6. Nariman Naber, Todd J. Minehardt, Sarah Rice, Xiaoru Chen, Jean Grammer, Maija Matuska, Roberto Car, Ronald D. Vale, Peter A. Kollman, Ralph G. Yount, Roger Cooke and Edward Pate, “The Nucleotide Pocket of Kinesin-Family Motors Closes Upon Binding to Microtubules”. Science, 300, 798-801 (2003).
7. Motomasa Tanaka, Peter Chin, Nariman Naber, Roger Cooke and Jonathan Wiessman, “Conformational Variations in an Infectious Protein Determine Prion Strain Differences”. Nature, 428, 323-328 (2004).
8. Nariman Naber, Thomas J. Purcell, Edward Pate and Roger Cooke, “Dynamics of the Nucleotide Pocket of Myosin Measured by Spin-Labled Nucleotide”. Biophys. J., 92, 172-184 (2007).
9. Thompson AR, Naber N, Wilson C, Cooke R, Thomas DD. Structural dynamics of the actomyosin complex probed by a bifunctional spin label that cross-links SH1 and SH2. Biophys J. 95, 5238-5246 (2008).
10. Wong YL, Dietrich KA, Naber N, Cooke R, Rice SE. The Kinesin-1 tail conformationally restricts the nucleotide pocket. Biophys J., 96, 2799-807 (2009).
11. Lisa R. Racki, Janet G. Yang, Nariman Naber, Peretz Partensky, Ashley Acevedo, Tom J. Purcell, Roger Cooke, Yifan Cheng, Geeta Narlikar,” The Chromatine remodeller AFC acts as dimeric motor to space nucleosomes”, Nature, 462, 1016-21( 2009).
12. Nariman Naber, András Málnási-Csizmadia, Roger Cooke, Edward Pate, “Combning EPR with Fluoresence spectroscopy to confirm a conformational change at the myosin nucleotide pocket”. J Mol Biol., 396, 937-48(2010)
13. Adam G. Larson, Nariman Naber, Roger Cooke, Edward Pate, and Sarah E. Rice. “The Conserved L5 loop establishes the prepower-stroke conformation of the kinesin-5 motor,Eg5” Biophys J., 98:2619-2627(2010)