Nariman Naber

Position:      Associate Biochemist
Specialty:    Organic Compound Synthesis, EPR
Phone:         (415) 476-1975
Fax:             (415) 476-1902
Email:          naber@itsa.ucsf.edu

Research Interests:
     - Bi-Functional Spin Probe Synthesis
    - Conformational changes in myosin, kinesin and ncd

Selected Publications:

• Closing of the nucleotide pocket of kinesin-family motors upon binding to microtubules.
  Naber, N., Minehardt, T.J., Rice, S., Chen, X., Grammer, J., Matuska, M., Vale, R.D., Kollman, P.A., Car, R., Yount. R.G., Cooke, R., Pate, E. Science, 300 (5620): 798-801 (2003).

• EPR Spectroscopy Shows a Microtubule-Dependent Conformational Change in the Kinesin Switch 1 Domain.
  Naber, N., Rice S., Matuska, M., Vale, R.D., Cooke, R., Pate, E. Biophysical Journal, 84 (5): 3190-3196 (2003).

• Thermodynamic Properties of the Kinesin Neck Region Docking to the Catalytic Core.
  Rice, S., Cui, Y., Sindelar, C.V., Naber, N., Matuska, M., Vale, R.D., Cooke R. Biophysical Journal, 84 (3): 1844-1854 (2003).

• Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy.
  Sindelar, C.V., Budny, M.J., Rice, S., Naber, N., Fletterick R., Cooke R. Nature Structural Biology, 9 (11): 844-848 (2002).

• A novel method of affinity-purifying proteins using a bis-arsenical fluorescein.
  Thorn, K.S., Naber, N., Matuska, M., Vale, R.D., Cooke R. Protein Science, 9 (2) 213-217 (2000).

• A Structural Change in the Kinesin Motor Protein that Drives Motility.
  Rice, S., A. W. Lin, D. Safer, C. L. Hart, N. Naber, B. O. Carragher, S. M. Cain, E. Pechatnikova, E. M. Wilson-Kubalek, M. Whittaker, E. Pate, R. Cooke, E. W. Taylor, R. A. Milligan, and R. D. Vale. Nature 402:778-784 (1999).
  
• Binding of ncd to Microtubules Induces a Conformational Change Near the Junction of the Motor Domain with the Neck
  Naber, N., Cooke, R., Pate, E. Biochemistry  36:  9681 - 9689  (1997).
  
• Opening of the Myosin Nucleotide Triphosphate Binding Domain During the ATPase Cycle
  Pate, E., Naber, N., Matuska, M., Franks-Skiba, K. and Cooke, R. Biochemistry  36:  (1997).
  
• A Novel Adenosine Triphosphate Analog with a Heavy Atom to Target the Nucleotide Binding Site of Proteins(Iodo-ATP)
  Naber, N., Matuska, M., Sablin, E.P., Pate, E. and Cooke, R. Protein Science  4: 1824-1831 (1995).