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Nuclear Architecture and Chromosome Organization

Our research is aimed at understanding the organization of chromosomes within the nucleus, the detailed architecture of the chromosomes themselves, and the functional roles this organization plays in determining chromosome behavior.

In order to carry out these studies we have developed several new methods of three-dimensional microscopy, including computerized wide-field deconvolution microscopy for multiwavelength fluorescence imaging of living cells, and electron tomography for three-dimensional imaging in the elctron microscope.

Learn More: Images of Nuclei and Chromosomes