ACS central science

Docking 14 Million Virtual Isoquinuclidines against the µ and ? Opioid Receptors Reveals Dual Antagonists–Inverse Agonists with Reduced Withdrawal Effects.

ACS central science

Seth F. Vigneron, Shohei Ohno, Joao Braz, Joseph Y. Kim, Oh Sang Kweon, Chase Webb, Christian B. Billesbølle, Karthik Srinivasan, Karnika Bhardwaj, John J. Irwin, Aashish Manglik, Allan I. Basbaum, Jonathan A. Ellman, Brian K. Shoichet

In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.

ACS central science

Zhao N, Bardine C, Lourenço AL, Wang YH, Huang Y, Cleary SJ, Wilson DM, Oh DY, Fong L, Looney MR, Evans MJ, Craik CS

GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf.

ACS central science

Zhang Z, Gao R, Hu Q, Peacock H, Peacock DM, Dai S, Shokat KM, Suga H

Sensing Living Bacteria in Vivo Using d-Alanine-Derived 11C Radiotracers.

ACS central science

Parker MFL, Luu JM, Schulte B, Huynh TL, Stewart MN, Sriram R, Yu MA, Jivan S, Turnbaugh PJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM

Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling.

ACS central science

Offenbacher AR, Hu S, Poss EM, Carr CAM, Scouras AD, Prigozhin DM, Iavarone AT, Palla A, Alber T, Fraser JS, Klinman JP

Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling.

ACS central science

Offenbacher AR, Hu S, Poss EM, Carr CAM, Scouras AD, Prigozhin DM, Iavarone AT, Palla A, Alber T, Fraser JS, Klinman JP