Assistant Professor
Cardiovascular Research Inst
+1 415 514-1133
Publications
Structures of the PI3Kα/KRas complex on lipid bilayers reveal the molecular mechanism of PI3Kα activation.
bioRxiv : the preprint server for biology
Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning.
bioRxiv : the preprint server for biology
G3BP isoforms differentially affect stress granule assembly and gene expression during cellular stress.
Molecular biology of the cell
Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.
bioRxiv : the preprint server for biology
Protein-protein interactions with G3BPs drive stress granule condensation and gene expression changes under cellular stress.
bioRxiv : the preprint server for biology
Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation.
bioRxiv : the preprint server for biology
Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma.
Research square
Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3.
Nature communications
Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase.
Structure (London, England : 1993)
Extensive conformational and physical plasticity protects HER2-HER3 tumorigenic signaling.
Cell reports
Structural basis for signaling by the HER3 pseudokinase receptor.
The FASEB Journal
CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids.
Nature communications
An effective strategy for ligand-mediated pulldown of the HER2/HER3/NRG1β heterocomplex and cryo-EM structure determination at low sample concentrations.
Methods in enzymology
Efficient expression, purification, and visualization by cryo-EM of unliganded near full-length HER3.
Methods in enzymology
Author Correction: Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.
Nature
Cryo-EM structures of the near full-length HER2/HER3 heterodimer reveal a novel allosteric mechanism of activation.
Biophysical journal
Extensive conformational and physical plasticity protects HER2-HER3 tumorigenic signaling.
Cell reports
Preface.
Methods in enzymology
Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.
The Journal of clinical investigation
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
Science (New York, N.Y.)
Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.
Nature communications
Mutant HER2 needs mutant HER3 to be an effective oncogene.
Cell reports. Medicine
Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.
bioRxiv : the preprint server for biology
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
Research square
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
bioRxiv : the preprint server for biology
State of the structure address on MET receptor activation by HGF.
Biochemical Society transactions
A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics.
Scientific reports
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
Science advances
Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.
Communications biology
Drugging the 'undruggable' MYCN oncogenic transcription factor: Overcoming previous obstacles to impact childhood cancers.
Cancer research
Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking.
bioRxiv : the preprint server for biology
Expression and Purification of Active Human Kinases Using Pichia pastoris as A General-Purpose Host.
Protein expression and purification
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Science (New York, N.Y.)
The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia.
Nature structural & molecular biology
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
bioRxiv : the preprint server for biology
Receptor tyrosine kinase activation: From the ligand perspective.
Current opinion in cell biology
The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.
The Journal of biological chemistry
PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization.
Proceedings of the National Academy of Sciences of the United States of America
Prospects for pharmacological targeting of pseudokinases.
Nature reviews. Drug discovery
Functional role of PGAM5 multimeric assemblies and their polymerization into filaments.
Nature communications
The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export.
The EMBO journal
Overexpression-mediated activation of MET in the Golgi promotes HER3/ERBB3 phosphorylation.
Oncogene
Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations.
Cancer cell
Activating HER3 mutations in breast cancer.
Oncotarget
Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23.
Structure (London, England : 1993)
Feedback regulation of RTK signaling in development.
Developmental biology
Switching on BTK-One Domain at a Time.
Structure (London, England : 1993)
EGF and NRG induce phosphorylation of HER3/ERBB3 by EGFR using distinct oligomeric mechanisms.
Proceedings of the National Academy of Sciences of the United States of America
Structural Basis for the Non-catalytic Functions of Protein Kinases.
Structure (London, England : 1993)
Src defines a new pool of EGFR substrates.
Nature structural & molecular biology
Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.
Molecular and cellular biology
Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Science signaling
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.
The Biochemical journal
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
Cancer cell
EGFR lung cancer mutants get specialized.
Proceedings of the National Academy of Sciences of the United States of America
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
Molecular cell
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
Proceedings of the National Academy of Sciences of the United States of America
Mapping cellular routes of Ras: a ubiquitin trail.
Cell cycle (Georgetown, Tex.)
A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen.
Gastroenterology
Differential modification of Ras proteins by ubiquitination.
Molecular cell
An ex vivo model for functional studies of myofibroblasts.
Laboratory investigation; a journal of technical methods and pathology
Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis.
Infection and immunity
Tumour necrosis factor-alpha stimulates expression of TNF-alpha converting enzyme in endothelial cells.
European journal of biochemistry
Inactivation of Src family kinases inhibits angiogenesis in vivo: implications for a mechanism involving organization of the actin cytoskeleton.
Experimental cell research
hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl.
Current biology : CB