Adam Frost, PhD, MD

Associate Professor
Biochemistry and BIophysics
+1 415 514-4825
Publications: 

Structural basis of mitochondrial receptor binding and constriction by DRP1.

Nature

Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.

eLife

Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky J, Frost A, Borner GH, Weissman JS

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.

Science (New York, N.Y.)

Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P

CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides.

Science (New York, N.Y.)

Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.

Proceedings of the National Academy of Sciences of the United States of America

Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A

Membrane fission by dynamin: what we know and what we need to know.

The EMBO journal

Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S

A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP.

The EMBO journal

Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ

Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex.

Nature structural & molecular biology

Heider MR, Gu M, Duffy CM, Mirza AM, Marcotte LL, Walls AC, Farrall N, Hakhverdyan Z, Field MC, Rout MP, Frost A, Munson M

Structure and membrane remodeling activity of ESCRT-III helical polymers.

Science (New York, N.Y.)

McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A

Structural and functional studies of membrane remodeling machines.

Methods in cell biology

Kalia R, Talledge N, Frost A

Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.

Science (New York, N.Y.)

Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A

Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.

Proceedings of the National Academy of Sciences of the United States of America

Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM

A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress.

Cell

Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS

Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions.

Cell

Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS

Structural basis of membrane bending by the N-BAR protein endophilin.

Cell

Mim C, Cui H, Gawronski-Salerno JA, Frost A, Lyman E, Voth GA, Unger VM

The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis.

Cell

Guerrier S, Coutinho-Budd J, Sassa T, Gresset A, Jordan NV, Chen K, Jin WL, Frost A, Polleux F

Structural basis of membrane invagination by F-BAR domains.

Cell

Frost A, Perera R, Roux A, Spasov K, Destaing O, Egelman EH, De Camilli P, Unger VM

F-BAR proteins join the BAR family fold.

Structure (London, England : 1993)

Frost A, De Camilli P, Unger VM

Noncontact dipole effects on channel permeation. VI. 5F- and 6F-Trp gramicidin channel currents.

Biophysical journal

Cole CD, Frost AS, Thompson N, Cotten M, Cross TA, Busath DD

The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors.

Molecular cell

Lax I, Wong A, Lamothe B, Lee A, Frost A, Hawes J, Schlessinger J