Daniel Minor, PhD

PROF-HCOMP
Cardiovascular Research Institute
+1 415 514-2551
Publications: 

A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function.

Neuron

Chang A, Abderemane-Ali F, Hura GL, Rossen ND, Gate RE, Minor DL

Global versus local mechanisms of temperature sensing in ion channels.

Pflugers Archiv : European journal of physiology

Arrigoni C, Minor DL

Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent.

Structure (London, England : 1993)

Ely LK, Lolicato M, David T, Lowe K, Kim YC, Samuel D, Bessette P, Garcia JL, Mikita T, Minor DL, Coughlin SR

Cryo-EM structures of the TMEM16A calcium-activated chloride channel.

Nature

Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY

K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.

Nature

Lolicato M, Arrigoni C, Mori T, Sekioka Y, Bryant C, Clark KA, Minor DL

Stapled Voltage-Gated Calcium Channel (CaV) a-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.

ACS chemical neuroscience

Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL

Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.

Cell

Arrigoni C, Rohaim A, Shaya D, Findeisen F, Stein RA, Nurva SR, Mishra S, Mchaourab HS, Minor DL

Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries.

ACS chemical neuroscience

Bagriantsev SN, Chatelain FC, Clark KA, Alagem N, Reuveny E, Minor DL

Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels.

Journal of molecular biology

Shaya D, Findeisen F, Abderemane-Ali F, Arrigoni C, Wong S, Nurva SR, Loussouarn G, Minor DL

A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.

ACS chemical biology

Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC).

Proceedings of the National Academy of Sciences of the United States of America

Tien J, Lee HY, Minor DL, Jan YN, Jan LY

Using yeast to study potassium channel function and interactions with small molecules.

Methods in molecular biology (Clifton, N.J.)

Bagriantsev SN, Minor DL

A glutamate switch controls voltage-sensitive phosphatase function.

Nature structural & molecular biology

Liu L, Kohout SC, Xu Q, Müller S, Kimberlin CR, Isacoff EY, Minor DL

Multiple modalities converge on a common gate to control K2P channel function.

The EMBO journal

Bagriantsev SN, Peyronnet R, Clark KA, Honoré E, Minor DL

Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins.

Proceedings of the National Academy of Sciences of the United States of America

Shaya D, Kreir M, Robbins RA, Wong S, Hammon J, Brüggemann A, Minor DL

Calmodulin overexpression does not alter Cav1.2 function or oligomerization state.

Channels (Austin, Tex.)

Findeisen F, Tolia A, Arant R, Kim EY, Isacoff E, Minor DL

Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.

The EMBO journal

Kim EY, Rumpf CH, Van Petegem F, Arant RJ, Findeisen F, Cooley ES, Isacoff EY, Minor DL

Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP.

Nature chemical biology

Kohout SC, Bell SC, Liu L, Xu Q, Minor DL, Isacoff EY

Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block.

PloS one

Chatelain FC, Gazzarrini S, Fujiwara Y, Arrigoni C, Domigan C, Ferrara G, Pantoja C, Thiel G, Moroni A, Minor DL

2007 annual progress report synopsis of the Center for Structures of Membrane Proteins.

Journal of structural and functional genomics

Stroud RM, Choe S, Holton J, Kaback HR, Kwiatkowski W, Minor DL, Riek R, Sali A, Stahlberg H, Harries W

A green fluorescent protein screen for identification of well-expressed membrane proteins from a cohort of extremophilic organisms.

Protein science : a publication of the Protein Society

Hammon J, Palanivelu DV, Chen J, Patel C, Minor DL

Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation.

Structure (London, England : 1993)

Kim EY, Rumpf CH, Fujiwara Y, Cooley ES, Van Petegem F, Minor DL

Structural insight into KCNQ (Kv7) channel assembly and channelopathy.

Neuron

Howard RJ, Clark KA, Holton JM, Minor DL

Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer.

Nature structural & molecular biology

Pioletti M, Findeisen F, Hura GL, Minor DL

A sensitive channel family replete with sense and motion.

Nature structural & molecular biology

Minor DL

The pore helix dipole has a minor role in inward rectifier channel function.

Neuron

Chatelain FC, Alagem N, Xu Q, Pancaroglu R, Reuveny E, Minor DL

The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.

Molecular cell

Walden H, Podgorski MS, Huang DT, Miller DW, Howard RJ, Minor DL, Holton JM, Schulman BA