
Professor
Cardiovascular Research Institute
+1 415 514-2836
Publications
CACNA1D is a circadian gene and causes familial advanced sleep phase.
Proceedings of the National Academy of Sciences of the United States of America
Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins.
Nature communications
Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.
Nature structural & molecular biology
Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.
Nature structural & molecular biology
Electrosome assembly: Structural insights from high voltage-activated calcium channel (CaV)-chaperone interactions.
Biochemical Society transactions
Development of covalent chemogenetic K2P channel activators.
Cell chemical biology
Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site.
bioRxiv : the preprint server for biology
Development of covalent chemogenetic K 2P channel activators.
bioRxiv : the preprint server for biology
Structural basis for CaVa2d:gabapentin binding.
Nature structural & molecular biology
Selective posttranslational inhibition of CaV�1-associated voltage-dependent calcium channels with a functionalized nanobody.
Nature communications
Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proceedings of the National Academy of Sciences of the United States of America
Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Nature structural & molecular biology
Differential effects of modified batrachotoxins on voltage-gated sodium channel fast and slow inactivation.
Cell chemical biology
Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on "toxin sponge" proteins.
The Journal of general physiology
Inroads into membrane physiology through transport nanomachines.
Journal of molecular biology
Ion channels: Intersection of Structure, Function, and Pharmacology.
Journal of molecular biology
Structural insights into the mechanisms and pharmacology of K2P potassium channels.
Journal of molecular biology
Production of K2P2.1 (TREK-1) for structural studies.
Methods in enzymology
Preface.
Methods in enzymology
Preface.
Methods in enzymology
Preface.
Methods in enzymology
The Polysite Pharmacology of TREK K2P Channels.
Advances in experimental medicine and biology
K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Science advances
Polynuclear Ruthenium Amines Inhibit K2P Channels via a "Finger in the Dam" Mechanism.
Cell chemical biology
Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Science advances
SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped ß-Sandwich Fold Important for SOCE Modulation.
Journal of molecular biology
A Selectivity Filter Gate Controls Voltage-Gated Calcium Channel Calcium-Dependent Inactivation.
Neuron
Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels.
ACS chemical neuroscience
Global versus local mechanisms of temperature sensing in ion channels.
Pflugers Archiv : European journal of physiology
Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent.
Structure (London, England : 1993)
Channel surfing uncovers a dual-use transporter.
The EMBO journal
Stapled Voltage-Gated Calcium Channel (CaV) a-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.
ACS chemical neuroscience
Insights into the molecular foundations of electrical excitation.
Journal of molecular biology
Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.
Journal of molecular biology
Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries.
ACS chemical neuroscience
Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels.
Journal of molecular biology
Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain.
Journal of molecular biology
A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.
ACS chemical biology
Patch-clamp characterization of the MscS-like mechanosensitive channel from Silicibacter pomeroyi.
Biophysical journal
Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC).
Proceedings of the National Academy of Sciences of the United States of America
Using yeast to study potassium channel function and interactions with small molecules.
Methods in molecular biology (Clifton, N.J.)
Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation.
Journal of molecular biology
Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains.
The EMBO journal
A glutamate switch controls voltage-sensitive phosphatase function.
Nature structural & molecular biology
Chemical informatics and target identification in a zebrafish phenotypic screen.
Nature chemical biology
Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins.
Proceedings of the National Academy of Sciences of the United States of America
Calmodulin overexpression does not alter Cav1.2 function or oligomerization state.
Channels (Austin, Tex.)
Structural basis for the differential effects of CaBP1 and calmodulin on Ca(V)1.2 calcium-dependent inactivation.
Structure (London, England : 1993)
Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation.
Channels (Austin, Tex.)
Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.
The EMBO journal
Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP.
Nature chemical biology
Crystal structure of a trimeric form of the K(V)7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif.
Protein science : a publication of the Protein Society
Searching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function.
Molecular bioSystems
Disruption of the IS6-AID linker affects voltage-gated calcium channel inactivation and facilitation.
The Journal of general physiology
2007 annual progress report synopsis of the Center for Structures of Membrane Proteins.
Journal of structural and functional genomics
A green fluorescent protein screen for identification of well-expressed membrane proteins from a cohort of extremophilic organisms.
Protein science : a publication of the Protein Society
Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation.
Structure (London, England : 1993)
X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil.
Journal of molecular biology
Transmembrane domain length of viral K+ channels is a signal for mitochondria targeting.
Proceedings of the National Academy of Sciences of the United States of America
Alanine-scanning mutagenesis defines a conserved energetic hotspot in the CaValpha1 AID-CaVbeta interaction site that is critical for channel modulation.
Structure (London, England : 1993)
Puzzle plugged by protein pore plasticity.
Molecular cell
Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer.
Nature structural & molecular biology
Wanting contact: how to pick up a channel.
Nature chemical biology
A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast.
Traffic (Copenhagen, Denmark)
A sensitive channel family replete with sense and motion.
Nature structural & molecular biology
Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex.
Nature structural & molecular biology
Bend to open?
Structure (London, England : 1993)
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
Molecular cell
Consensus-derived structural determinants of the ankyrin repeat motif.
Proceedings of the National Academy of Sciences of the United States of America