Jonathan Weissman, PhD

Spatiotemporal modeling of molecular holograms.

Cell

Qiu X, Zhu DY, Lu Y, Yao J, Jing Z, Min KH, Cheng M, Pan H, Zuo L, King S, Fang Q, Zheng H, Wang M, Wang S, Zhang Q, Yu S, Liao S, Liu C, Wu X, Lai Y, Hao S, Zhang Z, Wu L, Zhang Y, Li M, Tu Z, Lin J, Yang Z, Li Y, Gu Y, Ellison D, Chen A, Liu L, Weissman JS, Ma J, Xu X, Liu S, Bai Y

Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis.

bioRxiv : the preprint server for biology

Jones MG, Sun D, Min KHJ, Colgan WN, Tian L, Weir JA, Chen VZ, Koblan LW, Yost KE, Mathey-Andrews N, Russell AJC, Stickels RR, Balderrama KS, Rideout WM, Chang HY, Jacks T, Chen F, Weissman JS, Yosef N, Yang D

Multi-species genome-wide CRISPR screens identify GPX4 as a conserved suppressor of cold-induced cell death.

bioRxiv : the preprint server for biology

Lam B, Kajderowicz KM, Keys HR, Roessler JM, Frenkel EM, Kirkland A, Bisht P, El-Brolosy MA, Jaenisch R, Bell GW, Weissman JS, Griffith EC, Hrvatin S

High-quality peptide evidence for annotating non-canonical open reading frames as human proteins.

bioRxiv : the preprint server for biology

Deutsch EW, Kok LW, Mudge JM, Ruiz-Orera J, Fierro-Monti I, Sun Z, Abelin JG, Alba MM, Aspden JL, Bazzini AA, Bruford EA, Brunet MA, Calviello L, Carr SA, Carvunis AR, Chothani S, Clauwaert J, Dean K, Faridi P, Frankish A, Hubner N, Ingolia NT, Magrane M, Martin MJ, Martinez TF, Menschaert G, Ohler U, Orchard S, Rackham O, Roucou X, Slavoff SA, Valen E, Wacholder A, Weissman JS, Wu W, Xie Z, Choudhary J, Bassani-Sternberg M, Vizcaíno JA, Ternette N, Moritz RL, Prensner JR, van Heesch S

Robustness and reliability of single-cell regulatory multi-omics with deep mitochondrial mutation profiling.

bioRxiv : the preprint server for biology

Weng C, Weissman JS, Sankaran VG

Transcriptome-wide characterization of genetic perturbations.

bioRxiv : the preprint server for biology

Nadig A, Replogle JM, Pogson AN, McCarroll SA, Weissman JS, Robinson EB, O'Connor LJ

Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor.

Science (New York, N.Y.)

Neumann EN, Bertozzi TM, Wu E, Serack F, Harvey JW, Brauer PP, Pirtle CP, Coffey A, Howard M, Kamath N, Lenz K, Guzman K, Raymond MH, Khalil AS, Deverman BE, Minikel EV, Vallabh SM, Weissman JS

Author Correction: CRISPR technologies for genome, epigenome and transcriptome editing.

Nature reviews. Molecular cell biology

Villiger L, Joung J, Koblan L, Weissman J, Abudayyeh OO, Gootenberg JS

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress.

Developmental cell

Do BT, Hsu PP, Vermeulen SY, Wang Z, Hirz T, Abbott KL, Aziz N, Replogle JM, Bjelosevic S, Paolino J, Nelson SA, Block S, Darnell AM, Ferreira R, Zhang H, Milosevic J, Schmidt DR, Chidley C, Harris IS, Weissman JS, Pikman Y, Stegmaier K, Cheloufi S, Su XA, Sykes DB, Vander Heiden MG

CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling.

Proceedings of the National Academy of Sciences of the United States of America

Halasz H, Malekos E, Covarrubias S, Yitiz S, Montano C, Sudek L, Katzman S, Liu SJ, Horlbeck MA, Namvar L, Weissman JS, Carpenter S

Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.

Nature neuroscience

Hacisuleyman E, Hale CR, Noble N, Luo JD, Fak JJ, Saito M, Chen J, Weissman JS, Darnell RB

Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.

Molecular cell

Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS

CRISPR technologies for genome, epigenome and transcriptome editing.

Nature reviews. Molecular cell biology

Villiger L, Joung J, Koblan L, Weissman J, Abudayyeh OO, Gootenberg JS

Deciphering cell states and genealogies of human hematopoiesis.

Nature

Weng C, Yu F, Yang D, Poeschla M, Liggett LA, Jones MG, Qiu X, Wahlster L, Caulier A, Hussmann JA, Schnell A, Yost KE, Koblan L, Martin-Rufino JD, Min J, Hammond A, Ssozi D, Bueno R, Mallidi H, Kreso A, Escabi J, Rideout WM, Jacks T, Hormoz S, van Galen P, Weissman JS, Sankaran VG

Author Correction: Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning.

Nature biotechnology

Koblan LW, Arbab M, Shen MW, Hussmann JA, Anzalone AV, Doman JL, Newby GA, Yang D, Mok B, Replogle JM, Xu A, Sisley TA, Weissman JS, Adamson B, Liu DR

A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens.

BMC genomics

Guna A, Page KR, Replogle JM, Esantsi TK, Wang ML, Weissman JS, Voorhees RM

Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq.

Nature communications

Sunshine S, Puschnik AS, Replogle JM, Laurie MT, Liu J, Zha BS, Nuñez JK, Byrum JR, McMorrow AH, Frieman MB, Winkler J, Qiu X, Rosenberg OS, Leonetti MD, Ye CJ, Weissman JS, DeRisi JL, Hein MY

Triaging of ⍺-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.

bioRxiv : the preprint server for biology

Muthukumar G, Stevens TA, Inglis AJ, Esantsi TK, Saunders RA, Schulte F, Voorhees RM, Guna A, Weissman JS

A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens.

bioRxiv : the preprint server for biology

Guna A, Page KR, Replogle JR, Esantsi TK, Wang ML, Weissman JS, Voorhees RM

Translational fidelity screens in mammalian cells reveal eIF3 and eIF4G2 as regulators of start codon selectivity.

Nucleic acids research

She R, Luo J, Weissman JS

Comparative landscape of genetic dependencies in human and chimpanzee stem cells.

Cell

She R, Fair T, Schaefer NK, Saunders RA, Pavlovic BJ, Weissman JS, Pollen AA

FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer.

Research square

Tulpule A, Menon S, Breese M, Lin Y, Allegakoen H, Perati S, Heslin A, Horlbeck M, Weissman J, Sweet-Cordero A, Bivona T

FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer.

bioRxiv : the preprint server for biology

Menon S, Breese MR, Lin YP, Allegakoen H, Perati S, Heslin A, Horlbeck MA, Weissman J, Sweet-Cordero EA, Bivona TG, Tulpule A

Coupled protein quality control during nonsense-mediated mRNA decay.

Journal of cell science

Inglis AJ, Guna A, Gálvez-Merchán Á, Pal A, Esantsi TK, Keys HR, Frenkel EM, Oania R, Weissman JS, Voorhees RM

Comparative landscape of genetic dependencies in human and chimpanzee stem cells.

bioRxiv : the preprint server for biology

She R, Fair T, Schaefer NK, Saunders RA, Pavlovic BJ, Weissman JS, Pollen AA

Microfluidics-free single-cell genomics with templated emulsification.

Nature biotechnology

Clark IC, Fontanez KM, Meltzer RH, Xue Y, Hayford C, May-Zhang A, D'Amato C, Osman A, Zhang JQ, Hettige P, Ishibashi JSA, Delley CL, Weisgerber DW, Replogle JM, Jost M, Phong KT, Kennedy VE, Peretz CAC, Kim EA, Song S, Karlon W, Weissman JS, Smith CC, Gartner ZJ, Abate AR

Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors.

eLife

Replogle JM, Bonnar JL, Pogson AN, Liem CR, Maier NK, Ding Y, Russell BJ, Wang X, Leng K, Guna A, Norman TM, Pak RA, Ramos DM, Ward ME, Gilbert LA, Kampmann M, Weissman JS, Jost M

GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma.

JCI insight

Morales J, Allegakoen DV, Garcia JA, Kwong K, Sahu PK, Fajardo DA, Pan Y, Horlbeck MA, Weissman JS, Gustafson WC, Bivona TG, Sabnis AJ

MTCH2 is a mitochondrial outer membrane protein insertase.

Science (New York, N.Y.)

Guna A, Stevens TA, Inglis AJ, Replogle JM, Esantsi TK, Muthukumar G, Shaffer KCL, Wang ML, Pogson AN, Jones JJ, Lomenick B, Chou TF, Weissman JS, Voorhees RM

Cellular barcoding to decipher clonal dynamics in disease.

Science (New York, N.Y.)

Sankaran VG, Weissman JS, Zon LI

Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells.

Cell genomics

Wu D, Poddar A, Ninou E, Hwang E, Cole MA, Liu SJ, Horlbeck MA, Chen J, Replogle JM, Carosso GA, Eng NWL, Chang J, Shen Y, Weissman JS, Lim DA

Adaptive exchange sustains cullin-RING ubiquitin ligase networks and proper licensing of DNA replication.

Proceedings of the National Academy of Sciences of the United States of America

Zhang Y, Jost M, Pak RA, Lu D, Li J, Lomenick B, Garbis SD, Li CM, Weissman JS, Lipford JR, Deshaies RJ

Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice.

Nature biotechnology

Tolani B, Celli A, Yao Y, Tan YZ, Fetter R, Liem CR, de Smith AJ, Vasanthakumar T, Bisignano P, Cotton AD, Seiple IB, Rubinstein JL, Jost M, Weissman JS

A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities.

Cell chemical biology

Shao H, Taguwa S, Gilbert L, Shkedi A, Sannino S, Guerriero CJ, Gale-Day ZJ, Young ZT, Brodsky JL, Weissman J, Gestwicki JE, Frydman J

Standardized annotation of translated open reading frames.

Nature biotechnology

Mudge JM, Ruiz-Orera J, Prensner JR, Brunet MA, Calvet F, Jungreis I, Gonzalez JM, Magrane M, Martinez TF, Schulz JF, Yang YT, Albà MM, Aspden JL, Baranov PV, Bazzini AA, Bruford E, Martin MJ, Calviello L, Carvunis AR, Chen J, Couso JP, Deutsch EW, Flicek P, Frankish A, Gerstein M, Hubner N, Ingolia NT, Kellis M, Menschaert G, Moritz RL, Ohler U, Roucou X, Saghatelian A, Weissman JS, van Heesch S

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.

Cell

Replogle JM, Saunders RA, Pogson AN, Hussmann JA, Lenail A, Guna A, Mascibroda L, Wagner EJ, Adelman K, Lithwick-Yanai G, Iremadze N, Oberstrass F, Lipson D, Bonnar JL, Jost M, Norman TM, Weissman JS

Variant to function mapping at single-cell resolution through network propagation.

Nature biotechnology

Yu F, Cato LD, Weng C, Liggett LA, Jeon S, Xu K, Chiang CWK, Wiemels JL, Weissman JS, de Smith AJ, Sankaran VG

Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution.

Cell

Yang D, Jones MG, Naranjo S, Rideout WM, Min KHJ, Ho R, Wu W, Replogle JM, Page JL, Quinn JJ, Horns F, Qiu X, Chen MZ, Freed-Pastor WA, McGinnis CS, Patterson DM, Gartner ZJ, Chow ED, Bivona TG, Chan MM, Yosef N, Jacks T, Weissman JS

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Science (New York, N.Y.)

Cho NH, Cheveralls KC, Brunner AD, Kim K, Michaelis AC, Raghavan P, Kobayashi H, Savy L, Li JY, Canaj H, Kim JYS, Stewart EM, Gnann C, McCarthy F, Cabrera JP, Brunetti RM, Chhun BB, Dingle G, Hein MY, Huang B, Mehta SB, Weissman JS, Gómez-Sjöberg R, Itzhak DN, Royer LA, Mann M, Leonetti MD

High-content CRISPR screening.

Nature reviews. Methods primers

Bock C, Datlinger P, Chardon F, Coelho MA, Dong MB, Lawson KA, Lu T, Maroc L, Norman TM, Song B, Stanley G, Chen S, Garnett M, Li W, Moffat J, Qi LS, Shapiro RS, Shendure J, Weissman JS, Zhuang X

Mapping transcriptomic vector fields of single cells.

Cell

Qiu X, Zhang Y, Martin-Rufino JD, Weng C, Hosseinzadeh S, Yang D, Pogson AN, Hein MY, Hoi Joseph Min K, Wang L, Grody EI, Shurtleff MJ, Yuan R, Xu S, Ma Y, Replogle JM, Lander ES, Darmanis S, Bahar I, Sankaran VG, Xing J, Weissman JS

Variant to function mapping at single-cell resolution through network propagation.

bioRxiv : the preprint server for biology

Yu F, Cato LD, Weng C, Liggett LA, Jeon S, Xu K, Chiang CWK, Wiemels JL, Weissman JS, de Smith AJ, Sankaran VG

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.

Nature cell biology

Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M

Peroxisome function relies on organelle-associated mRNA translation.

Science advances

Dahan N, Bykov YS, Boydston EA, Fadel A, Gazi Z, Hochberg-Laufer H, Martenson J, Denic V, Shav-Tal Y, Weissman JS, Aviram N, Zalckvar E, Schuldiner M

The dark proteome: translation from noncanonical open reading frames.

Trends in cell biology

Wright BW, Yi Z, Weissman JS, Chen J

Functional single-cell genomics of human cytomegalovirus infection.

Nature biotechnology

Hein MY, Weissman JS

Mapping the genetic landscape of DNA double-strand break repair.

Cell

Hussmann JA, Ling J, Ravisankar P, Yan J, Cirincione A, Xu A, Simpson D, Yang D, Bothmer A, Cotta-Ramusino C, Weissman JS, Adamson B

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.

Cell

Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR

BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2.

bioRxiv : the preprint server for biology

Tian R, Samelson AJ, Rezelj VV, Chen M, Ramadoss GN, Guo X, Kain AM, Tran QD, Lim SA, Lui I, Nunez J, Rockwood SJ, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin B, Vignuzzi M, Kampmann M

Structured elements drive extensive circular RNA translation.

Molecular cell

Chen CK, Cheng R, Demeter J, Chen J, Weingarten-Gabbay S, Jiang L, Snyder MP, Weissman JS, Segal E, Jackson PK, Chang HY

An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens.

eLife

Coukos RW, Yao D, Sanchez ML, Strand ET, Olive ME, Udeshi ND, Weissman JS, Carr SA, Bassik MC, Ting AY

Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning.

Nature biotechnology

Koblan LW, Arbab M, Shen MW, Hussmann JA, Anzalone AV, Doman JL, Newby GA, Yang D, Mok B, Replogle JM, Xu A, Sisley TA, Weissman JS, Adamson B, Liu DR

Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.

eLife

Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, Horlbeck MA, Salemi MR, Phinney BS, Weissman JS, Nunnari J

CRISPR-based functional genomics in human dendritic cells.

eLife

Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.

Cell

Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS

Regulation of translation by methylation multiplicity of 18S rRNA.

Cell reports

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

Cell

Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA

High-content imaging-based pooled CRISPR screens in mammalian cells.

The Journal of cell biology

Yan X, Stuurman N, Ribeiro SA, Tanenbaum ME, Horlbeck MA, Liem CR, Jost M, Weissman JS, Vale RD

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts.

Science (New York, N.Y.)

Quinn JJ, Jones MG, Okimoto RA, Nanjo S, Chan MM, Yosef N, Bivona TG, Weissman JS

A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation.

Cancer discovery

Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Sobba WD, Karlsson K, Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, Chen J, Shmulevich I, Weissman JS, Curtis C, Califano A, Fu H, Crabtree GR, Kuo CJ

Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference.

Methods in molecular biology (Clifton, N.J.)

Liu SJ, Horlbeck MA, Weissman JS, Lim DA

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients.

eLife

Miller-Vedam LE, Bräuning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS

Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilis.

Cell systems

Hawkins JS, Silvis MR, Koo BM, Peters JM, Osadnik H, Jost M, Hearne CC, Weissman JS, Todor H, Gross CA

Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway.

Current biology : CB

Jiménez-Rojo N, Leonetti MD, Zoni V, Colom A, Feng S, Iyengar NR, Matile S, Roux A, Vanni S, Weissman JS, Riezman H

Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing.

Cell

Maynard A, McCoach CE, Rotow JK, Harris L, Haderk F, Kerr DL, Yu EA, Schenk EL, Tan W, Zee A, Tan M, Gui P, Lea T, Wu W, Urisman A, Jones K, Sit R, Kolli PK, Seeley E, Gesthalter Y, Le DD, Yamauchi KA, Naeger DM, Bandyopadhyay S, Shah K, Cech L, Thomas NJ, Gupta A, Gonzalez M, Do H, Tan L, Bacaltos B, Gomez-Sjoberg R, Gubens M, Jahan T, Kratz JR, Jablons D, Neff N, Doebele RC, Weissman J, Blakely CM, Darmanis S, Bivona TG

Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span.

Science advances

Zou K, Rouskin S, Dervishi K, McCormick MA, Sasikumar A, Deng C, Chen Z, Kaeberlein M, Brem RB, Polymenis M, Kennedy BK, Weissman JS, Zheng J, Ouyang Q, Li H

GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.

Molecular cell

Hickey KL, Dickson K, Cogan JZ, Replogle JM, Schoof M, D'Orazio KN, Sinha NK, Hussmann JA, Jost M, Frost A, Green R, Weissman JS, Kostova KK

Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent.

Molecular cell

Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS

Polysomes Bypass a 50 Nucleotide Coding Gap less Efficiently than Monosomes Due to Attenuation of a 5' mRNA Stem Loop and Enhanced Drop-off.

Journal of molecular biology

O'Loughlin S, Capece MC, Klimova M, Wills NM, Coakley A, Samatova E, O'Connor PBF, Loughran G, Weissman JS, Baranov PV, Rodnina MV, Puglisi JD, Atkins JF

Inference of single-cell phylogenies from lineage tracing data using Cassiopeia.

Genome biology

Jones MG, Khodaverdian A, Quinn JJ, Chan MM, Hussmann JA, Wang R, Xu C, Weissman JS, Yosef N

CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.

Genome biology

Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA

Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing.

Nature biotechnology

Replogle JM, Norman TM, Xu A, Hussmann JA, Chen J, Cogan JZ, Meer EJ, Terry JM, Riordan DP, Srinivas N, Fiddes IT, Arthur JG, Alvarado LJ, Pfeiffer KA, Mikkelsen TS, Weissman JS, Adamson B

Pervasive functional translation of noncanonical human open reading frames.

Science (New York, N.Y.)

Chen J, Brunner AD, Cogan JZ, Nuñez JK, Fields AP, Adamson B, Itzhak DN, Li JY, Mann M, Leonetti MD, Weissman JS

Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes.

Nature biotechnology

Horlbeck MA, Liu SJ, Chang HY, Lim DA, Weissman JS

Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs.

Nature biotechnology

Jost M, Santos DA, Saunders RA, Horlbeck MA, Hawkins JS, Scaria SM, Norman TM, Hussmann JA, Liem CR, Gross CA, Weissman JS

The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration.

Genes & development

Monahan Vargas EJ, Matamoros AJ, Qiu J, Jan CH, Wang Q, Gorczyca D, Han TW, Weissman JS, Jan YN, Banerjee S, Song Y

Variation in expenditure for common, high cost surgical procedures in a working age population: implications for reimbursement reform.

BMC health services research

Wynn-Jones W, Koehlmoos TP, Tompkins C, Navathe A, Lipsitz S, Kwon NK, Learn PA, Madsen C, Schoenfeld A, Weissman JS

The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins.

eLife

Ngo AM, Shurtleff MJ, Popova KD, Kulsuptrakul J, Weissman JS, Puschnik AS

New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.

The Journal of cell biology

Bassaganyas L, Popa SJ, Horlbeck M, Puri C, Stewart SE, Campelo F, Ashok A, Butnaru CM, Brouwers N, Heydari K, Ripoche J, Weissman J, Rubinsztein DC, Schekman R, Malhotra V, Moreau K, Villeneuve J

Exploring genetic interaction manifolds constructed from rich single-cell phenotypes.

Science (New York, N.Y.)

Norman TM, Horlbeck MA, Replogle JM, Ge AY, Xu A, Jost M, Gilbert LA, Weissman JS

MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices.

Nature methods

McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ

Cycloheximide can distort measurements of mRNA levels and translation efficiency.

Nucleic acids research

Santos DA, Shi L, Tu BP, Weissman JS

Ceapins block the unfolded protein response sensor ATF6a by inducing a neomorphic inter-organelle tether.

eLife

Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P

Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress.

Proceedings of the National Academy of Sciences of the United States of America

Igbaria A, Merksamer PI, Trusina A, Tilahun F, Johnson JR, Brandman O, Krogan NJ, Weissman JS, Papa FR

Molecular recording of mammalian embryogenesis.

Nature

Chan MM, Smith ZD, Grosswendt S, Kretzmer H, Norman TM, Adamson B, Jost M, Quinn JJ, Yang D, Jones MG, Khodaverdian A, Yosef N, Meissner A, Weissman JS

Ribosome Profiling: Global Views of Translation.

Cold Spring Harbor perspectives in biology

Ingolia NT, Hussmann JA, Weissman JS

Cellular response to small molecules that selectively stall protein synthesis by the ribosome.

PLoS genetics

Liaud N, Horlbeck MA, Gilbert LA, Gjoni K, Weissman JS, Cate JHD

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.

Molecular cell

Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV

Mapping the Genetic Landscape of Human Cells.

Cell

Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA

Exploration of Benzothiazole-Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).

Journal of medicinal chemistry

Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers LM, Gestwicki JE

Reprogramming human T cell function and specificity with non-viral genome targeting.

Nature

Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A

Engineering ER-stress dependent non-conventional mRNA splicing.

eLife

Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman JS, Walter P

The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs.

Nature

Guenther UP, Weinberg DE, Zubradt MM, Tedeschi FA, Stawicki BN, Zagore LL, Brar GA, Licatalosi DD, Bartel DP, Weissman JS, Jankowsky E

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.

eLife

Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky J, Frost A, Borner GH, Weissman JS

Combinatorial genetics in liver repopulation and carcinogenesis with a novel in vivo CRISPR activation platform.

Hepatology (Baltimore, Md.)

Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman JS, Berger SL, Kaestner KH

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates.

eLife

Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK

Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.

Cell

Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY

A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation.

Molecular cell

Zhang Y, Burkhardt DH, Rouskin S, Li GW, Weissman JS, Gross CA

CRISPR Approaches to Small Molecule Target Identification.

ACS chemical biology

Jost M, Weissman JS

Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins.

eLife

Martinko AJ, Truillet C, Julien O, Diaz JE, Horlbeck MA, Whiteley G, Blonder J, Weissman JS, Bandyopadhyay S, Evans MJ, Wells JA

Defining the physiological role of SRP in protein-targeting efficiency and specificity.

Science (New York, N.Y.)

Costa EA, Subramanian K, Nunnari J, Weissman JS

Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER.

Developmental cell

Friedman JR, Kannan M, Toulmay A, Jan CH, Weissman JS, Prinz WA, Nunnari J

The Human Cell Atlas.

eLife

Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim S, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe'er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N

Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors.

Nature methods

Tak YE, Kleinstiver BP, Nuñez JK, Hsu JY, Horng JE, Gong J, Weissman JS, Joung JK

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.

Molecular cell

Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS

CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides.

Science (New York, N.Y.)

Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS

Minimally invasive surgery and its impact on 30-day postoperative complications, unplanned readmissions and mortality.

The British journal of surgery

Sood A, Meyer CP, Abdollah F, Sammon JD, Sun M, Lipsitz SR, Hollis M, Weissman JS, Menon M, Trinh QD

Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia.

Blood

Kruth KA, Fang M, Shelton DN, Abu-Halawa O, Mahling R, Yang H, Weissman JS, Loh ML, Müschen M, Tasian SK, Bassik MC, Kampmann M, Pufall MA

Operon mRNAs are organized into ORF-centric structures that predict translation efficiency.

eLife

Burkhardt DH, Rouskin S, Zhang Y, Li GW, Weissman JS, Gross CA

Translation from unconventional 5' start sites drives tumour initiation.

Nature

Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman JS, Fuchs E

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.

Cell

Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.

Science (New York, N.Y.)

Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens.

Cell

Dixit A, Parnas O, Li B, Chen J, Fulco CP, Jerby-Arnon L, Marjanovic ND, Dionne D, Burks T, Raychowdhury R, Adamson B, Norman TM, Lander ES, Weissman JS, Friedman N, Regev A

The mTOR Complex Controls HIV Latency.

Cell host & microbe

Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum.

Nature

Aviram N, Ast T, Costa EA, Arakel EC, Chuartzman SG, Jan CH, Haßdenteufel S, Dudek J, Jung M, Schorr S, Zimmermann R, Schwappach B, Weissman JS, Schuldiner M

Plastid: nucleotide-resolution analysis of next-generation sequencing and genomics data.

BMC genomics

Dunn JG, Weissman JS

Model-guided optogenetic study of PKA signaling in budding yeast.

Molecular biology of the cell

Stewart-Ornstein J, Chen S, Bhatnagar R, Weissman JS, El-Samad H

DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo.

Nature methods

Zubradt M, Gupta P, Persad S, Lambowitz AM, Weissman JS, Rouskin S

Dynamic translation regulation in Caulobacter cell cycle control.

Proceedings of the National Academy of Sciences of the United States of America

Schrader JM, Li GW, Childers WS, Perez AM, Weissman JS, Shapiro L, McAdams HH

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.

eLife

Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS

Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.

Proceedings of the National Academy of Sciences of the United States of America

Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.

Nature communications

Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA

Htm1p-Pdi1p is a folding-sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation.

Proceedings of the National Academy of Sciences of the United States of America

Liu YC, Fujimori DG, Weissman JS

Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation.

Proceedings of the National Academy of Sciences of the United States of America

Braun CJ, Bruno PM, Horlbeck MA, Gilbert LA, Weissman JS, Hemann MT

A scalable strategy for high-throughput GFP tagging of endogenous human proteins.

Proceedings of the National Academy of Sciences of the United States of America

Leonetti MD, Sekine S, Kamiyama D, Weissman JS, Huang B

A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria.

Cell

Peters JM, Colavin A, Shi H, Czarny TL, Larson MH, Wong S, Hawkins JS, Lu CHS, Koo BM, Marta E, Shiver AL, Whitehead EH, Weissman JS, Brown ED, Qi LS, Huang KC, Gross CA

Single-cell analysis of long non-coding RNAs in the developing human neocortex.

Genome biology

Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein AR, Diaz AA, Lim DA

Versatile protein tagging in cells with split fluorescent protein.

Nature communications

Kamiyama D, Sekine S, Barsi-Rhyne B, Hu J, Chen B, Gilbert LA, Ishikawa H, Leonetti MD, Marshall WF, Weissman JS, Huang B

Nucleosomes impede Cas9 access to DNA in vivo and in vitro.

eLife

Horlbeck MA, Witkowsky LB, Guglielmi B, Replogle JM, Gilbert LA, Villalta JE, Torigoe SE, Tjian R, Weissman JS

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.

Cell stem cell

Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, Gilbert LA, Krogan NJ, Sheikh SP, Weissman JS, Qi LS, So PL, Conklin BR

A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation.

Molecular cell

Fields AP, Rodriguez EH, Jovanovic M, Stern-Ginossar N, Haas BJ, Mertins P, Raychowdhury R, Hacohen N, Carr SA, Ingolia NT, Regev A, Weissman JS

[KIL-d] Protein Element Confers Antiviral Activity via Catastrophic Viral Mutagenesis.

Molecular cell

Suzuki G, Weissman JS, Tanaka M

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis.

Cancer cell

Anderson DJ, Le Moigne R, Djakovic S, Kumar B, Rice J, Wong S, Wang J, Yao B, Valle E, Kiss von Soly S, Madriaga A, Soriano F, Menon MK, Wu ZY, Kampmann M, Chen Y, Weissman JS, Aftab BT, Yakes FM, Shawver L, Zhou HJ, Wustrow D, Rolfe M

Ribosome profiling reveals the what, when, where and how of protein synthesis.

Nature reviews. Molecular cell biology

Brar GA, Weissman JS

Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits.

eLife

Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M

Regulation of mRNA translation during mitosis.

eLife

Tanenbaum ME, Stern-Ginossar N, Weissman JS, Vale RD

Next-generation libraries for robust RNA interference-based genome-wide screens.

Proceedings of the National Academy of Sciences of the United States of America

Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman JS

LOCAL TRANSLATION. Response to Comment on "Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling".

Science (New York, N.Y.)

Jan CH, Williams CC, Weissman JS

Oncogenic activation of the PI3-kinase p110ß isoform via the tumor-derived PIK3Cß(D1067V) kinase domain mutation.

Oncogene

Pazarentzos E, Giannikopoulos P, Hrustanovic G, St John J, Olivas VR, Gubens MA, Balassanian R, Weissman J, Polkinghorn W, Bivona TG

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.

eLife

Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P

Corrigendum: functional genomics platform for pooled screening and generation of mammalian genetic interaction maps.

Nature protocols

Kampmann M, Bassik MC, Weissman JS

Biotechnology. A prudent path forward for genomic engineering and germline gene modification.

Science (New York, N.Y.)

Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR

Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens.

Science (New York, N.Y.)

Jovanovic M, Rooney MS, Mertins P, Przybylski D, Chevrier N, Satija R, Rodriguez EH, Fields AP, Schwartz S, Raychowdhury R, Mumbach MR, Eisenhaure T, Rabani M, Gennert D, Lu D, Delorey T, Weissman JS, Carr SA, Hacohen N, Regev A

Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer.

Molecular cancer therapeutics

Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE

Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.

Science (New York, N.Y.)

Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A

Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation.

Molecular systems biology

Pop C, Rouskin S, Ingolia NT, Han L, Phizicky EM, Weissman JS, Koller D

Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds.

Cell

Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA

Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling.

Science (New York, N.Y.)

Williams CC, Jan CH, Weissman JS

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling.

Science (New York, N.Y.)

Jan CH, Williams CC, Weissman JS

The general mode of translation inhibition by macrolide antibiotics.

Proceedings of the National Academy of Sciences of the United States of America

Kannan K, Kanabar P, Schryer D, Florin T, Oh E, Bahroos N, Tenson T, Weissman JS, Mankin AS

Genetic influences on translation in yeast.

PLoS genetics

Albert FW, Muzzey D, Weissman JS, Kruglyak L

A protein-tagging system for signal amplification in gene expression and fluorescence imaging.

Cell

Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.

Cell

Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS

Unraveling the mechanism of cell death induced by chemical fibrils.

Nature chemical biology

Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA

Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes.

Cell reports

Ingolia NT, Brar GA, Stern-Ginossar N, Harris MS, Talhouarne GJ, Jackson SE, Wills MR, Weissman JS

Misfolded proteins induce aggregation of the lectin Yos9.

The Journal of biological chemistry

Smith MH, Rodriguez EH, Weissman JS

The coding and noncoding architecture of the Caulobacter crescentus genome.

PLoS genetics

Schrader JM, Zhou B, Li GW, Lasker K, Childers WS, Williams B, Long T, Crosson S, McAdams HH, Weissman JS, Shapiro L

Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps.

Nature protocols

Kampmann M, Bassik MC, Weissman JS

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.

Nature communications

van de Weijer ML, Bassik MC, Luteijn RD, Voorburg CM, Lohuis MA, Kremmer E, Hoeben RC, LeProust EM, Chen S, Hoelen H, Ressing ME, Patena W, Weissman JS, McManus MT, Wiertz EJ, Lebbink RJ

A pause sequence enriched at translation start sites drives transcription dynamics in vivo.

Science (New York, N.Y.)

Larson MH, Mooney RA, Peters JM, Windgassen T, Nayak D, Gross CA, Block SM, Greenleaf WJ, Landick R, Weissman JS

Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources.

Cell

Li GW, Burkhardt D, Gross C, Weissman JS

Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicans.

Genome research

Muzzey D, Sherlock G, Weissman JS

Uniform nomenclature for the mitochondrial contact site and cristae organizing system.

The Journal of cell biology

Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J

Differential scales of protein quality control.

Cell

Wolff S, Weissman JS, Dillin A

KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features.

PLoS pathogens

Arias C, Weisburd B, Stern-Ginossar N, Mercier A, Madrid AS, Bellare P, Holdorf M, Weissman JS, Ganem D

Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.

Cell

Chen B, Gilbert LA, Cimini BA, Schnitzbauer J, Zhang W, Li GW, Park J, Blackburn EH, Weissman JS, Qi LS, Huang B

Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo.

Nature

Rouskin S, Zubradt M, Washietl S, Kellis M, Weissman JS

Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster.

eLife

Dunn JG, Foo CK, Belletier NG, Gavis ER, Weissman JS

Msn2 coordinates a stoichiometric gene expression program.

Current biology : CB

Stewart-Ornstein J, Nelson C, DeRisi J, Weissman JS, El-Samad H

Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens.

Chemistry & biology

Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman JS, Cleary ML

Global cellular response to chemotherapy-induced apoptosis.

eLife

Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA

CRISPR interference (CRISPRi) for sequence-specific control of gene expression.

Nature protocols

Larson MH, Gilbert LA, Wang X, Lim WA, Weissman JS, Qi LS

Selective ribosome profiling as a tool for studying the interaction of chaperones and targeting factors with nascent polypeptide chains and ribosomes.

Nature protocols

Becker AH, Oh E, Weissman JS, Kramer G, Bukau B

A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern.

Genes & development

Berchowitz LE, Gajadhar AS, van Werven FJ, De Rosa AA, Samoylova ML, Brar GA, Xu Y, Xiao C, Futcher B, Weissman JS, White FM, Amon A

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.

Cell

Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS

Genome-wide annotation and quantitation of translation by ribosome profiling.

Current protocols in molecular biology

Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman JS

Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins.

Cell

Guttman M, Russell P, Ingolia NT, Weissman JS, Lander ES

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America

Kampmann M, Bassik MC, Weissman JS

rRNA:mRNA pairing alters the length and the symmetry of mRNA-protected fragments in ribosome profiling experiments.

Bioinformatics (Oxford, England)

O'Connor PB, Li GW, Weissman JS, Atkins JF, Baranov PV

Aneuploid yeast strains exhibit defects in cell growth and passage through START.

Molecular biology of the cell

Thorburn RR, Gonzalez C, Brar GA, Christen S, Carlile TM, Ingolia NT, Sauer U, Weissman JS, Amon A

The contribution of systematic approaches to characterizing the proteins and functions of the endoplasmic reticulum.

Cold Spring Harbor perspectives in biology

Schuldiner M, Weissman JS

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

Cell

Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility.

Cell

Bassik MC, Kampmann M, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Chen S, Mann M, Hyman AA, Leproust EM, McManus MT, Weissman JS

Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.

Genome biology

Muzzey D, Schwartz K, Weissman JS, Sherlock G

Decoding human cytomegalovirus.

Science (New York, N.Y.)

Stern-Ginossar N, Weisburd B, Michalski A, Le VT, Hein MY, Huang SX, Ma M, Shen B, Qian SB, Hengel H, Mann M, Ingolia NT, Weissman JS

A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress.

Cell

Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments.

Nature protocols

Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman JS

Proto-genes and de novo gene birth.

Nature

Carvunis AR, Rolland T, Wapinski I, Calderwood MA, Yildirim MA, Simonis N, Charloteaux B, Hidalgo CA, Barbette J, Santhanam B, Brar GA, Weissman JS, Regev A, Thierry-Mieg N, Cusick ME, Vidal M

Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions.

Cell

Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS

Special issue: the molecular and cellular mechanisms of amyloidosis.

Journal of molecular biology

Radford SE, Weissman JS

Native elongating transcript sequencing (NET-seq).

Current protocols in molecular biology

Churchman LS, Weissman JS

The anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria.

Nature

Li GW, Oh E, Weissman JS

Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae.

Molecular cell

Stewart-Ornstein J, Weissman JS, El-Samad H

The translational landscape of mTOR signalling steers cancer initiation and metastasis.

Nature

Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D

High-resolution view of the yeast meiotic program revealed by ribosome profiling.

Science (New York, N.Y.)

Brar GA, Yassour M, Friedman N, Regev A, Ingolia NT, Weissman JS

Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo.

Cell

Oh E, Becker AH, Sandikci A, Huber D, Chaba R, Gloge F, Nichols RJ, Typas A, Gross CA, Kramer G, Weissman JS, Bukau B

Genetics: Noise rules.

Nature

El-Samad H, Weissman JS

Road to ruin: targeting proteins for degradation in the endoplasmic reticulum.

Science (New York, N.Y.)

Smith MH, Ploegh HL, Weissman JS

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America

Roelants FM, Breslow DK, Muir A, Weissman JS, Thorner J

Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes.

Cell

Ingolia NT, Lareau LF, Weissman JS

A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria.

The Journal of cell biology

Hoppins S, Collins SR, Cassidy-Stone A, Hummel E, Devay RM, Lackner LL, Westermann B, Schuldiner M, Weissman JS, Nunnari J

Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats.

Nature

Gracheva EO, Cordero-Morales JF, González-Carcacía JA, Ingolia NT, Manno C, Aranguren CI, Weissman JS, Julius D

H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway.

Molecular and cellular biology

Terzi N, Churchman LS, Vasiljeva L, Weissman J, Buratowski S

Strain conformation, primary structure and the propagation of the yeast prion [PSI+].

Nature structural & molecular biology

Verges KJ, Smith MH, Toyama BH, Weissman JS

Radically different amyloid conformations dictate the seeding specificity of a chimeric Sup35 prion.

Journal of molecular biology

Foo CK, Ohhashi Y, Kelly MJ, Tanaka M, Weissman JS

Nascent transcript sequencing visualizes transcription at nucleotide resolution.

Nature

Churchman LS, Weissman JS

Amyloid structure: conformational diversity and consequences.

Annual review of biochemistry

Toyama BH, Weissman JS

Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts.

Eukaryotic cell

Henry TC, Power JE, Kerwin CL, Mohammed A, Weissman JS, Cameron DM, Wykoff DD

The epistemology of cell biology.

Molecular biology of the cell

Weissman JS

Membranes in balance: mechanisms of sphingolipid homeostasis.

Molecular cell

Breslow DK, Weissman JS

Mammalian microRNAs predominantly act to decrease target mRNA levels.

Nature

Guo H, Ingolia NT, Weissman JS, Bartel DP

Automated identification of pathways from quantitative genetic interaction data.

Molecular systems biology

Battle A, Jonikas MC, Walter P, Weissman JS, Koller D

A general lack of compensation for gene dosage in yeast.

Molecular systems biology

Springer M, Weissman JS, Kirschner MW

J domain co-chaperone specificity defines the role of BiP during protein translocation.

The Journal of biological chemistry

Vembar SS, Jonikas MC, Hendershot LM, Weissman JS, Brodsky JL

Molecular basis of infrared detection by snakes.

Nature

Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, Sánchez EE, Perez JC, Weissman JS, Julius D

Orm family proteins mediate sphingolipid homeostasis.

Nature

Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, Ejsing CS, Weissman JS

Differences in prion strain conformations result from non-native interactions in a nucleus.

Nature chemical biology

Ohhashi Y, Ito K, Toyama BH, Weissman JS, Tanaka M

Journal club. A biochemist looks at how DNA sequencing can reveal more than just sequences.

Nature

Weissman J

From information to knowledge: new technologies for defining gene function.

Nature methods

Collins SR, Weissman JS, Krogan NJ

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells.

The Journal of cell biology

Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS

An ER-mitochondria tethering complex revealed by a synthetic biology screen.

Science (New York, N.Y.)

Kornmann B, Currie E, Collins SR, Schuldiner M, Nunnari J, Weissman JS, Walter P

Rapid creation and quantitative monitoring of high coverage shRNA libraries.

Nature methods

Bassik MC, Lebbink RJ, Churchman LS, Ingolia NT, Patena W, LeProust EM, Schuldiner M, Weissman JS, McManus MT

Analysis of Dom34 and its function in no-go decay.

Molecular biology of the cell

Passos DO, Doma MK, Shoemaker CJ, Muhlrad D, Green R, Weissman J, Hollien J, Parker R

Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.

Science (New York, N.Y.)

Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M

Functional organization of the S. cerevisiae phosphorylation network.

Cell

Fiedler D, Braberg H, Mehta M, Chechik G, Cagney G, Mukherjee P, Silva AC, Shales M, Collins SR, van Wageningen S, Kemmeren P, Holstege FC, Weissman JS, Keogh MC, Koller D, Shokat KM, Krogan NJ

Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling.

Science (New York, N.Y.)

Ingolia NT, Ghaemmaghami S, Newman JR, Weissman JS

Defining the glycan destruction signal for endoplasmic reticulum-associated degradation.

Molecular cell

Quan EM, Kamiya Y, Kamiya D, Denic V, Weibezahn J, Kato K, Weissman JS

A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing.

Molecular cell

Wilmes GM, Bergkessel M, Bandyopadhyay S, Shales M, Braberg H, Cagney G, Collins SR, Whitworth GB, Kress TL, Weissman JS, Ideker T, Guthrie C, Krogan NJ

In vivo monitoring of the prion replication cycle reveals a critical role for Sis1 in delivering substrates to Hsp104.

Molecular cell

Tipton KA, Verges KJ, Weissman JS

Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network.

Nature biotechnology

Chechik G, Oh E, Rando O, Weissman J, Regev A, Koller D

Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Science (New York, N.Y.)

Roguev A, Bandyopadhyay S, Zofall M, Zhang K, Fischer T, Collins SR, Qu H, Shales M, Park HO, Hayles J, Hoe KL, Kim DU, Ideker T, Grewal SI, Weissman JS, Krogan NJ

High-throughput, quantitative analyses of genetic interactions in E. coli.

Nature methods

Typas A, Nichols RJ, Siegele DA, Shales M, Collins SR, Lim B, Braberg H, Yamamoto N, Takeuchi R, Wanner BL, Mori H, Weissman JS, Krogan NJ, Gross CA

Systems biology: Reverse engineering the cell.

Nature

Ingolia NT, Weissman JS

The GET complex mediates insertion of tail-anchored proteins into the ER membrane.

Cell

Schuldiner M, Metz J, Schmid V, Denic V, Rakwalska M, Schmitt HD, Schwappach B, Weissman JS

A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.

Nature methods

Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman JS

Small-molecule aggregates inhibit amyloid polymerization.

Nature chemical biology

Feng BY, Toyama BH, Wille H, Colby DW, Collins SR, May BC, Prusiner SB, Weissman J, Shoichet BK

Identification of yeast proteins necessary for cell-surface function of a potassium channel.

Proceedings of the National Academy of Sciences of the United States of America

Haass FA, Jonikas M, Walter P, Weissman JS, Jan YN, Jan LY, Schuldiner M

High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe.

Nature methods

Roguev A, Wiren M, Weissman JS, Krogan NJ

The structural basis of yeast prion strain variants.

Nature

Toyama BH, Kelly MJ, Gross JD, Weissman JS

A molecular caliper mechanism for determining very long-chain fatty acid length.

Cell

Denic V, Weissman JS

Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses.

Cell

Morrison AJ, Kim JA, Person MD, Highland J, Xiao J, Wehr TS, Hensley S, Bao Y, Shen J, Collins SR, Weissman JS, Delrow J, Krogan NJ, Haber JE, Shen X

Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss.

Molecular systems biology

Ihmels J, Collins SR, Schuldiner M, Krogan NJ, Weissman JS

CCR4/NOT complex associates with the proteasome and regulates histone methylation.

Proceedings of the National Academy of Sciences of the United States of America

Laribee RN, Shibata Y, Mersman DP, Collins SR, Kemmeren P, Roguev A, Weissman JS, Briggs SD, Krogan NJ, Strahl BD

Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map.

Nature

Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP, Weissman JS, Greenblatt JF, Krogan NJ

Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae.

Molecular & cellular proteomics : MCP

Collins SR, Kemmeren P, Zhao XC, Greenblatt JF, Spencer F, Holstege FC, Weissman JS, Krogan NJ

Quantitative genetic analysis in Saccharomyces cerevisiae using epistatic miniarray profiles (E-MAPs) and its application to chromatin functions.

Methods (San Diego, Calif.)

Schuldiner M, Collins SR, Weissman JS, Krogan NJ

Systems biology: many things from one.

Nature

Newman JR, Weissman JS

A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation.

Cell

Denic V, Quan EM, Weissman JS

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

Science (New York, N.Y.)

Hollien J, Weissman JS

The physical basis of how prion conformations determine strain phenotypes.

Nature

Tanaka M, Collins SR, Toyama BH, Weissman JS

Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise.

Nature

Newman JR, Ghaemmaghami S, Ihmels J, Breslow DK, Noble M, DeRisi JL, Weissman JS

Molecular chaperones and protein quality control.

Cell

Bukau B, Weissman J, Horwich A

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.

Nature

Krogan NJ, Cagney G, Yu H, Zhong G, Guo X, Ignatchenko A, Li J, Pu S, Datta N, Tikuisis AP, Punna T, Peregrín-Alvarez JM, Shales M, Zhang X, Davey M, Robinson MD, Paccanaro A, Bray JE, Sheung A, Beattie B, Richards DP, Canadien V, Lalev A, Mena F, Wong P, Starostine A, Canete MM, Vlasblom J, Wu S, Orsi C, Collins SR, Chandran S, Haw R, Rilstone JJ, Gandi K, Thompson NJ, Musso G, St Onge P, Ghanny S, Lam MH, Butland G, Altaf-Ul AM, Kanaya S, Shilatifard A, O'Shea E, Weissman JS, Ingles CJ, Hughes TR, Parkinson J, Gerstein M, Wodak SJ, Emili A, Greenblatt JF

A strategy for extracting and analyzing large-scale quantitative epistatic interaction data.

Genome biology

Collins SR, Schuldiner M, Krogan NJ, Weissman JS

An efficient protein transformation protocol for introducing prions into yeast.

Methods in enzymology

Tanaka M, Weissman JS

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.

Cell

Keogh MC, Kurdistani SK, Morris SA, Ahn SH, Podolny V, Collins SR, Schuldiner M, Chin K, Punna T, Thompson NJ, Boone C, Emili A, Weissman JS, Hughes TR, Strahl BD, Grunstein M, Greenblatt JF, Buratowski S, Krogan NJ

Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation.

The Journal of biological chemistry

Kulp MS, Frickel EM, Ellgaard L, Weissman JS

Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.

Cell

Schuldiner M, Collins SR, Thompson NJ, Denic V, Bhamidipati A, Punna T, Ihmels J, Andrews B, Boone C, Greenblatt JF, Weissman JS, Krogan NJ

Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen.

Molecular cell

Bhamidipati A, Denic V, Quan EM, Weissman JS

Mechanism of cross-species prion transmission: an infectious conformation compatible with two highly divergent yeast prion proteins.

Cell

Tanaka M, Chien P, Yonekura K, Weissman JS

Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains.

Comparative and functional genomics

Howson R, Huh WK, Ghaemmaghami S, Falvo JV, Bower K, Belle A, Dephoure N, Wykoff DD, Weissman JS, O'Shea EK

2004 Irving Sigal Young Investigator Award.

Protein science : a publication of the Protein Society

Weissman JS, O'Shea EK

Mechanism of prion propagation: amyloid growth occurs by monomer addition.

PLoS biology

Collins SR, Douglass A, Vale RD, Weissman JS

Dissection and design of yeast prions.

PLoS biology

Osherovich LZ, Cox BS, Tuite MF, Weissman JS

Conformational variations in an infectious protein determine prion strain differences.

Nature

Tanaka M, Chien P, Naber N, Cooke R, Weissman JS

Oxidative protein folding in eukaryotes: mechanisms and consequences.

The Journal of cell biology

Tu BP, Weissman JS

Emerging principles of conformation-based prion inheritance.

Annual review of biochemistry

Chien P, Weissman JS, DePace AH

Global analysis of protein expression in yeast.

Nature

Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS

Global analysis of protein localization in budding yeast.

Nature

Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK

Generation of prion transmission barriers by mutational control of amyloid conformations.

Nature

Chien P, DePace AH, Collins SR, Weissman JS

Directed evolution of substrate-optimized GroEL/S chaperonins.

Cell

Wang JD, Herman C, Tipton KA, Gross CA, Weissman JS

The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum.

Molecular cell

Tu BP, Weissman JS

Origins and kinetic consequences of diversity in Sup35 yeast prion fibers.

Nature structural biology

DePace AH, Weissman JS

The utility of prions.

Developmental cell

Osherovich LZ, Weissman JS

Prion diseases. A rogue protein.

Lancet (London, England)

Weissman JS, Hood JK

The ins and outs of GroEL-mediated protein folding.

Molecular cell

Weissman JS

Preparedness for clinical practice: reports of graduating residents at academic health centers.

JAMA

Blumenthal D, Gokhale M, Campbell EG, Weissman JS

Racial differences in cardiac revascularization rates: does "overuse" explain higher rates among white patients?

Annals of internal medicine

Schneider EC, Leape LL, Weissman JS, Piana RN, Gatsonis C, Epstein AM

Residents' preferences and preparation for caring for underserved populations.

Journal of urban health : bulletin of the New York Academy of Medicine

Weissman JS, Campbell EG, Gokhale M, Blumenthal D

The relationship of market forces to the satisfaction of faculty at academic health centers.

The American journal of medicine

Blumenthal D, Causino N, Campbell EG, Weissman JS

Status of clinical research in academic health centers: views from the research leadership.

JAMA

Campbell EG, Weissman JS, Moy E, Blumenthal D

Multiple Gln/Asn-rich prion domains confer susceptibility to induction of the yeast [PSI(+)] prion.

Cell

Osherovich LZ, Weissman JS

Conformational diversity in a yeast prion dictates its seeding specificity.

Nature

Chien P, Weissman JS

The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly.

The Journal of cell biology

Aridor M, Fish KN, Bannykh S, Weissman J, Roberts TH, Lippincott-Schwartz J, Balch WE

Functional genomic approaches to understanding molecular chaperones and stress responses.

Advances in protein chemistry

Travers KJ, Patil CK, Weissman JS

The action of molecular chaperones in the early secretory pathway.

Annual review of genetics

Fewell SW, Travers KJ, Weissman JS, Brodsky JL

Understanding the relationship between market competition and students' ratings of the managed care content of their undergraduate medical education.

Academic medicine : journal of the Association of American Medical Colleges

Campbell EG, Weissman JS, Ausiello J, Wyatt S, Blumenthal D

Biochemical basis of oxidative protein folding in the endoplasmic reticulum.

Science (New York, N.Y.)

Tu BP, Ho-Schleyer SC, Travers KJ, Weissman JS

Racial disparities in access to renal transplantation--clinically appropriate or due to underuse or overuse?

The New England journal of medicine

Epstein AM, Ayanian JZ, Keogh JH, Noonan SJ, Armistead N, Cleary PD, Weissman JS, David-Kasdan JA, Carlson D, Fuller J, Marsh D, Conti RM

Unmet health needs of uninsured adults in the United States.

JAMA

Ayanian JZ, Weissman JS, Schneider EC, Ginsburg JA, Zaslavsky AM

A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions.

Proceedings of the National Academy of Sciences of the United States of America

Michelitsch MD, Weissman JS

Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein.

Science (New York, N.Y.)

Sparrer HE, Santoso A, Szoka FC, Weissman JS

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation.

Cell

Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS, Walter P

Stage-specific assays to study biosynthetic cargo selection and role of SNAREs in export from the endoplasmic reticulum and delivery to the Golgi.

Methods (San Diego, Calif.)

Allan BB, Weissman J, Aridor M, Moyer B, Chen CD, Yoo JS, Balch WE

Molecular basis of a yeast prion species barrier.

Cell

Santoso A, Chien P, Osherovich LZ, Weissman JS

Quality of care by race and gender for congestive heart failure and pneumonia.

Medical care

Ayanian JZ, Weissman JS, Chasan-Taber S, Epstein AM

The effect of patients' preferences on racial differences in access to renal transplantation.

The New England journal of medicine

Ayanian JZ, Cleary PD, Weissman JS, Epstein AM

Academic health centers on the front lines: survival strategies in highly competitive markets.

Academic medicine : journal of the Association of American Medical Colleges

Blumenthal D, Weissman JS, Griner PF

Thinking outside the box: new insights into the mechanism of GroEL-mediated protein folding.

Nature structural biology

Wang JD, Weissman JS

Hospital readmissions and quality of care.

Medical care

Weissman JS, Ayanian JZ, Chasan-Taber S, Sherwood MJ, Roth C, Epstein AM

Market forces and unsponsored research in academic health centers.

JAMA

Weissman JS, Saglam D, Campbell EG, Causino N, Blumenthal D

Termination from Medicaid: how does it affect access, continuity of care, and willingness to purchase insurance?

Journal of health care for the poor and underserved

Weissman JS, Witzburg R, Linov P, Campbell EG

The stability of preferences for life-sustaining care among persons with AIDS in the Boston Health Study.

Medical decision making : an international journal of the Society for Medical Decision Making

Weissman JS, Haas JS, Fowler FJ, Gatsonis C, Massagli MP, Seage GR, Cleary P

GroEL-GroES-mediated protein folding requires an intact central cavity.

Proceedings of the National Academy of Sciences of the United States of America

Wang JD, Michelitsch MD, Weissman JS

A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion.

Cell

DePace AH, Santoso A, Hillner P, Weissman JS

Costs and outcomes of AIDS care: comparing a health maintenance organization with fee-for-service systems in the Boston Health Study.

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association

Wilson IB, Sullivan LM, Weissman JS

The influence of health-related quality of life and social characteristics on hospital use by patients with AIDS in the Boston Health Study.

Medical care

Weissman JS, Cleary PD, Seage GR, Gatsonis C, Haas JS, Chasan-Taber S, Epstein AM

Utilization of formal and informal home care by AIDS patients in Boston: a comparison of intravenous drug users and homosexual males.

Medical care

Ettner SL, Weissman J

Physician discretion and racial variation in the use of surgical procedures.

Archives of internal medicine

Mort EA, Weissman JS, Epstein AM

The impact of patient socioeconomic status and other social factors on readmission: a prospective study in four Massachusetts hospitals.

Inquiry : a journal of medical care organization, provision and financing

Weissman JS, Stern RS, Epstein AM

Acute aortic thrombosis causing sudden paraplegia in a patient with known thoraco-lumbar spinal metastasis: the diagnostic usefulness of magnetic resonance imaging.

Neurosurgery

Moore MR, Blatter DD, Weissman J, Tyler HR

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Jonathan Weissman, PhD