- Principal Investigators
- David Agard, PhD
- Yifan Cheng, PhD
- Charles Craik, PhD
- Seemay Chou, PhD
- Roger Cooke, PhD
- James Fraser, PhD
- Adam Frost, PhD, MD
- John Gross, PhD
- Natalia Jura, PhD
- Wendell Lim, PhD
- Aashish Manglik, PhD, MD
- Daniel Minor, PhD
- Oren Rosenberg, MD, PhD
- John Sedat
- Kevan Shokat, PhD
- Robert Stroud, PhD
- Jonathan Weissman, PhD
- Allison Williams, PhD
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John Gross, PhD
Professor
Pharmaceutical Chemistry
+1 415 502-1897
We investigate molecular machines that coordinate gene expression or antiviral immunity. Research areas include : i- RNA decay enzymes that act in mRNA quality control and gene regulatory pathways, and ii- nucleic acid based immune systems that protect animals from viruses and neutralization of these systems by viral accessory proteins. We use tools from molecular biophysics to understand the structure and regulatory conformational dynamics in these systems with the ultimate goal of defining molecular mechanisms and avenues for structure based drug design.
Publications: