Natalia Jura, PhD

Assistant Professor
Cardiovascular Research Inst
+1 415 514-1133
Publications: 

An International Multi-Center Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of CASQ2- Catecholaminergic Polymorphic Ventricular Tachycardia.

Circulation

Ng K, Titus EW, Lieve KV, Roston TM, Mazzanti A, Deiter FH, Denjoy I, Ingles J, Till J, Robyns T, Connors SP, Steinberg C, Abrams DJ, Pang B, Scheinman MM, Bos JM, Duffett SA, van der Werf C, Maltret A, Green MS, Rutberg J, Balaji S, Cadrin-Tourigny J, Orland KM, Knight LM, Brateng C, Wu J, Tang AS, Skanes AC, Manlucu J, Healey JS, January CT, Krahn AD, Collins KK, Maginot KR, Fischbach P, Etheridge SP, Eckhardt LL, Hamilton RM, Ackerman MJ, Rosés I Noguer F, Semsarian C, Jura N, Leenhardt A, Gollob MH, Priori SG, Sanatani S, Wilde AAM, Deo RC, Roberts JD

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

Nature

Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.

bioRxiv : the preprint server for biology

Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Lin Y, Wankowicz SA, Bohn M, Trenker R, Young JM, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Agard D, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ

Receptor tyrosine kinase activation: From the ligand perspective.

Current opinion in cell biology

Trenker R, Jura N

The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.

The Journal of biological chemistry

Agnew C, Liu L, Liu S, Xu W, You L, Yeung W, Kannan N, Jablons D, Jura N

PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization.

Proceedings of the National Academy of Sciences of the United States of America

Lopez ML, Lo M, Kung JE, Dudkiewicz M, Jang GM, Von Dollen J, Johnson JR, Krogan NJ, Pawlowski K, Jura N

Prospects for pharmacological targeting of pseudokinases.

Nature reviews. Drug discovery

Kung JE, Jura N

Functional role of PGAM5 multimeric assemblies and their polymerization into filaments.

Nature communications

Ruiz K, Thaker TM, Agnew C, Miller-Vedam L, Trenker R, Herrera C, Ingaramo M, Toso D, Frost A, Jura N

Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations.

Cancer cell

Pahuja KB, Nguyen TT, Jaiswal BS, Prabhash K, Thaker TM, Senger K, Chaudhuri S, Kljavin NM, Antony A, Phalke S, Kumar P, Mravic M, Stawiski EW, Vargas D, Durinck S, Gupta R, Khanna-Gupta A, Trabucco SE, Sokol ES, Hartmaier RJ, Singh A, Chougule A, Trivedi V, Dutt A, Patil V, Joshi A, Noronha V, Ziai J, Banavali SD, Ramprasad V, DeGrado WF, Bueno R, Jura N, Seshagiri S

Activating HER3 mutations in breast cancer.

Oncotarget

Mishra R, Alanazi S, Yuan L, Solomon T, Thaker TM, Jura N, Garrett JT

Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras.

Cell reports

Liang SI, van Lengerich B, Eichel K, Cha M, Patterson DM, Yoon TY, von Zastrow M, Jura N, Gartner ZJ

Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23.

Structure (London, England : 1993)

Liu L, Thaker TM, Freed DM, Frazier N, Malhotra K, Lemmon MA, Jura N

Feedback regulation of RTK signaling in development.

Developmental biology

Neben CL, Lo M, Jura N, Klein OD

Switching on BTK-One Domain at a Time.

Structure (London, England : 1993)

Agnew C, Jura N

EGF and NRG induce phosphorylation of HER3/ERBB3 by EGFR using distinct oligomeric mechanisms.

Proceedings of the National Academy of Sciences of the United States of America

van Lengerich B, Agnew C, Puchner EM, Huang B, Jura N

Structural Basis for the Non-catalytic Functions of Protein Kinases.

Structure (London, England : 1993)

Kung JE, Jura N

Src defines a new pool of EGFR substrates.

Nature structural & molecular biology

Michael N, Jura N

Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.

Molecular and cellular biology

Kovacs E, Das R, Wang Q, Collier TS, Cantor A, Huang Y, Wong K, Mirza A, Barros T, Grob P, Jura N, Bose R, Kuriyan J

Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.

Science signaling

Littlefield P, Liu L, Mysore V, Shan Y, Shaw DE, Jura N

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.

The Biochemical journal

Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K, Tripaydonis A, Jura N, Fukuda K, Qin J, Nimchuk Z, Mudgett MB, Elowe S, Gee CL, Liu L, Daly RJ, Manning G, Babon JJ, Lucet IS

EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.

Cancer cell

Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA

EGFR lung cancer mutants get specialized.

Proceedings of the National Academy of Sciences of the United States of America

Littlefield P, Jura N

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.

Molecular cell

Jura N, Zhang X, Endres NF, Seeliger MA, Schindler T, Kuriyan J

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.

Proceedings of the National Academy of Sciences of the United States of America

Jura N, Shan Y, Cao X, Shaw DE, Kuriyan J

Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.

Cell

Jura N, Endres NF, Engel K, Deindl S, Das R, Lamers MH, Wemmer DE, Zhang X, Kuriyan J

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.

Nature

Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J

Mapping cellular routes of Ras: a ubiquitin trail.

Cell cycle (Georgetown, Tex.)

Jura N, Bar-Sagi D

A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen.

Gastroenterology

Archer H, Jura N, Keller J, Jacobson M, Bar-Sagi D

Differential modification of Ras proteins by ubiquitination.

Molecular cell

Jura N, Scotto-Lavino E, Sobczyk A, Bar-Sagi D

An ex vivo model for functional studies of myofibroblasts.

Laboratory investigation; a journal of technical methods and pathology

Kilarski WW, Jura N, Gerwins P

Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis.

Infection and immunity

Mezyk-Kopec R, Bzowska M, Potempa J, Bzowska M, Jura N, Sroka A, Black RA, Bereta J

Tumour necrosis factor-alpha stimulates expression of TNF-alpha converting enzyme in endothelial cells.

European journal of biochemistry

Bzowska M, Jura N, Lassak A, Black RA, Bereta J

hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl.

Current biology : CB

Hall AB, Jura N, DaSilva J, Jang YJ, Gong D, Bar-Sagi D