Seemay Chou, PhD

Department of Biochemistry and Biophysics
+1 415 653-8989

We study the mechanistic forces that drive animal–microbe interactions. Our lab takes an interdisciplinary approach in order to understand these relationships at multiple levels, ranging from atomic to organismal.


Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context.


Radkov A, Sapiro AL, Flores S, Henderson C, Saunders H, Kim R, Massa S, Thompson S, Mateusiak C, Biboy J, Zhao Z, Starita LM, Hatleberg WL, Vollmer W, Russell AB, Simorre JP, Anthony-Cahill S, Brzovic P, Hayes B, Chou S

Host blood meal identity modifies vector gene expression and competency.

Molecular ecology

Ring K, Couper LI, Sapiro AL, Yarza F, Yang XF, Clay K, Mateusiak C, Chou S, Swei A

The cyclic dinucleotide 2'3'-cGAMP induces a broad antibacterial and antiviral response in the sea anemone Nematostella vectensis.

Proceedings of the National Academy of Sciences of the United States of America

Margolis SR, Dietzen PA, Hayes BM, Wilson SC, Remick BC, Chou S, Vance RE

Ticks Resist Skin Commensals with Immune Factor of Bacterial Origin.


Hayes BM, Radkov AD, Yarza F, Flores S, Kim J, Zhao Z, Lexa KW, Marnin L, Biboy J, Bowcut V, Vollmer W, Pedra JHF, Chou S

Differential modes of crosslinking establish spatially distinct regions of peptidoglycan in Caulobacter crescentus.

Molecular microbiology

Stankeviciute G, Miguel AV, Radkov A, Chou S, Huang KC, Klein EA

Ixodes scapularis does not harbor a stable midgut microbiome.

The ISME journal

Ross BD, Hayes B, Radey MC, Lee X, Josek T, Bjork J, Neitzel D, Paskewitz S, Chou S, Mougous JD

Identification, structure, and function of a novel type VI secretion peptidoglycan glycoside hydrolase effector-immunity pair.

The Journal of biological chemistry

Whitney JC, Chou S, Russell AB, Biboy J, Gardiner TE, Ferrin MA, Brittnacher M, Vollmer W, Mougous JD

Structure of a peptidoglycan amidase effector targeted to Gram-negative bacteria by the type VI secretion system.

Cell reports

Chou S, Bui NK, Russell AB, Lexa KW, Gardiner TE, LeRoux M, Vollmer W, Mougous JD

Structural basis for type VI secretion effector recognition by a cognate immunity protein.

PLoS pathogens

Li M, Le Trong I, Carl MA, Larson ET, Chou S, De Leon JA, Dove SL, Stenkamp RE, Mougous JD

Purification and characterization of HIV-human protein complexes.

Methods (San Diego, Calif.)

Jäger S, Gulbahce N, Cimermancic P, Kane J, He N, Chou S, D'Orso I, Fernandes J, Jang G, Frankel AD, Alber T, Zhou Q, Krogan NJ