Research

My research focuses on understanding how the molecular chaperone, Hsp90, interacts with client proteins. With Ray Wang, I am studying how Hsp90 regulates the folding maturation of an obligate client, the glucocorticoid receptor (GR). Using this model client system and a combination of biochemical and structural approaches, we aim to elucidate a molecular understanding of how Hsp90 interacts with clients during folding, how ATP hydrolysis is coupled to client maturation, and how co-chaperones affect the Hsp90-client maturation cycle.

Publications

5. *Noddings CM, *Wang RY-R, Johnson, JL, Agard, DA (2021). Structure of Hsp90-p23-GR reveals the Hsp90 client-remodeling mechanism. Nature (in press).  (bioRxiv preprint doi: https://doi.org/10.1101/2020.09.12.294975)

4. Wang RY-R, Noddings CM, Kirschke, E, Myasnikov, AG, Johnson, JL, Agard, DA (2021). Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Nature (in press). (bioRxiv preprint doi: https://doi.org/10.1101/2020.11.05.370247)

3. Kirschke E, Roe-Zurz Z, Noddings C, Agard D (2020). The interplay between Bag-1, Hsp70, and Hsp90 reveals that inhibiting Hsp70 rebinding is essential for Glucocorticoid Receptor activity. BioRxiv. 

2. Diner RE, Noddings CM, Lian NC, Kang AK, McQuaid JB, Jablanovic J, ... Weyman PD (2017). Diatom Centromeres Suggest a Novel Mechanism for Nuclear Gene Acquisition. PNAS.

1. Karas BJ, Diner RE, Lefebvre SC, Mcquaid J, Phillips AP, Noddings CM, ... Weyman PD (2015). Designer diatom episomes delivered by bacterial conjugation. Nature Communications.