UCSF MC 2240
Genentech Hall Room S412F
600 16th St.
San Francisco, CA 94158-2517
Office: (415) 514-4179
Fax: (415) 476-1902
email

Cooke Lab Publications

1.  Cooke, R., Tsibris, J.C.M., Debrunner, P.G., Tsai, R., Gunsalus, I.C. and Frauenfelder, H.  Mossbauer Studies on Putidaredoxin.  Proc. Nat'l. Acad. Sci., 59:1045-1052 (1968).

2.  Cooke, R. and Debrunner, P.  Mossbauer Studies of the Iron Atom in Cytochrome C.  J. Chem. Phys., 48:4532-4537 (1968).

3.  Cooke, R.  Enzyme Studies using the Mossbauer Effect.  Mossbauer Effect Methodology, Vol. 4, Plenum Press, (1968) (Invited paper).

4.  Cooke, R. and Morales, M.  Spin Label Studies of Glycerinated Muscle Fibers.  Biochem. 8:3188-3194 (1969).

5.  Quinlivan, J., McConnel, M.H., Stowring, L., Cooke, R. and Morales, M.F.  Myosin Modification as Studied by Spin-Labelling.  Biochem., 8:3644-3647 (1969).

6.  Cheung, H. and Cooke, R.  Effects of Alkali Ions on Myosin Conformation.  Biopolymers 10:523-529 (1971).

7.  Cheung, H., Cooke, R. and Smith, L.  The G Actin F Actin Transformation as Studied by the Fluorescence of Bound Dansyl Cystine.  Arch. Biochem. Biophys. 142:333-339 (1971).

8.  Cooke, R. and Morales, M.  The Interaction of Globular Actin with Myosin Subfragments.  J. Mol. Biol. 60:249-261 (1971).

9.  Cooke, R. and Wien, R.  The State of Water in Muscle Tissue as Determined by Proton Nuclear Magnetic Resonance.  J. Biophys. 11:1002-1017 (1971).

10.  Cooke, R. and Duke, J.  Synthesis and some Properties of a Spin Label Analog of Adenosine 5' Triphosphate.  J. Biol. Chem. 246:6360-6369 (1971).

11.  Cooke, R.  A New Method for Producing Myosin Subfragment-1.  Biochem. Biophys. Res. Comm. 49:1021-1028 (1972).

12.  Cooke, R. and Wien, R.  Nuclear Magnetic Resonance Studies of Intracellular Water Protons.  Annal. N.Y. Acad. Sci. 204:197-209 (1973). (Invited paper).

13.  Botts, J., Cooke, R., dos Remedios, C., Duke, J., Mendelson, R., Morales, M.F., Tokiwa, T., Viniegra, G. and Yount, R.  Does a Myosin Cross-bridge Progress Arm-over-arm on the Actin Filament?  Cold Spring Harbor Symposium on Quantitative Biology 37:195-200 (1973).

14.  Cooke, R. and Murdoch, L.  Interaction of Actin with Analogs of Adenosine Triphosphate.  Biochem. 12:3927-3932 (1973).

15.  Cooke, R. and Kuntz, I.D.  The Properties of Water in Biological Systems.  Ann. Rev. Biophys. Bioeng. 3:95-126 (1974) (Invited paper).

16.  Cooke, R.  Spin Label Probes of the Intracellular Aqueous Environment.  CNRS International Colloquium 246:283-287 (1975).

17.  Cooke, R.  The Role of the Bound Nucleotide in the Polymerization of Actin.  Biochemistry 14:3250-3256 (1975).

18.  Spudich, J.A. and Cooke, R.  Supramolecular Forms of Actin from Amoebae of Dictyostelium Discoideum.  J. Biol. Chem. 250:7485-7491 (1975).

19.  Cooke, R.  The Bound Nucleotide of Actin.  J. Supramol. Biol.  3:146-153 (1975).

20.  Cooke, R., Clark, M., von Wedel, R.J., and Spudich, J.A.  Supramolecular Forms of Dictyostelium Actin.  Cold Spring Harbor Conferences on Cell Proliferation 3:575-587 (1976).

21.  Crooks, R., and Cooke, R.  Generation of Forces by Actin and Myosin in Biological Motile Structures, Workshop on New Directions for Kinematics Research (Proc. of Natl Sci. Foundation) B. Roth, ed. (1976).

22.  Crooks, R., and Cooke, R.  Tension Generation by Threads of Contractile Proteins.  J. Gen. Physiol. 69:37-55 (1977).

23.  Cooke, R. and Franks, K.  The Generation of Force by Single-Headed Myosin.  J. Mol. Biol. 120:361-373 (1978).

24.  Lebowitz, E. and Cooke, R.  The Contractile Properties of Human Blood Platelet Actomyosin.  J. Biol. Chem., 253:5443-5447 (1978).

25.  Johnson, D.A., Cooke, R., and Loh, H.H.  Involvement of Lipids in the Action of Ethanol and Other Anaesthetics, International Symposium on Biological Research in Alcoholism, Begleiter and Kisser, eds., Plenum Press, New York, pp. 65-68 (1979)  (Invited paper).

26.  Johnson, D.A., Lee, N.M., and Cooke, R.  Adaptation to Ethanol-Induced Fluidization of Brain Lipid Bilayers.  Drug and Alcohol Dependence, 4:197-202 (1979).

27.  Toste, A. and Cooke, R.  Interaction of Contractile Proteins with Cibacron Blue F3Ga.  Anal. Biochem. 95:317-328 (1979).

28.  Lebowitz, E. and Cooke, R.  Phosphorylation of Uterine Smooth Muscle Myosin Permits Actin-Activation.  J. Biochem.  85:1489-1494 (1979).

29.  Johnson, D.A., Cooke, R. and Loh, H.H.  Effect of Opiate Agonists and Antagonists on Lipid Bilayer Fluidity.  J. Mol. Pharmacology  16:154-162 (1979).

30.  Johnson, D.A., Lee, N.M., Cooke, R., and Loh, H.H.  Ethanol-Induced Fluidization of Brain Lipid Bilayers:  Role of Cholesterol in Expression of Tolerance.  J. Mol. Pharmacology 15:739-746 (1979).

31.  Cooke, R. and Bialek, W., The Contraction of Glycerinated Muscle Fibers as a Function of the ATP Concentration.  Biophysics J. 28:241-258 (1979).

32.  Sobel, J.S., Cooke, R. and Pedersen, R.A.  Distribution of Actin and Myosin in Mouse Trophoblast:  Correlation with Changes in Invasiveness During Development In Vitro.  Dev. Biol. 78:365-379 (1980).

33.  Cooke, R., and Franks, K., All Myosin Heads Form Bonds with Actin in Rigor Rabbit Skeletal Muscle.  Biochem. 19:2265-2269 (1980).

34.  Srivastava, S., Cooke, R., and Wikman-Coffelt, J.  Studies on the Role of Myosin Light Chain -LC2 in Tension Generation.  Biochem. Biophys. Res. Comm. 92:1-7 (1980).

35.  Johnson, D.A., Lee, N.M., Cooke, R., and Loh, H.  Adaptation to Ethanol-Induced Fluidization of Brain Lipid Bilayers: Cross-Tolerance and Reversibility.  J. Mol. Pharmacology 17:52-55.

36.  Johnson, D.A., Friedman, H.J., Cooke, R. and Lee, N.M.  Adaptation of Brain Lipid Bilayers to Ethanol-Induced Fluidization:  Species and Strain Generality.  Biochem. Pharmacol. 29:1673-1676 (1980).

37.  Ritz-Gold, C.J., Cooke, R. Blumenthal, D.K. and Stull, J.T.  Light Chain Phosphorylation Alters the Conformation of Skeletal Muscle Myosin.  Biochem. Biophys. Res. Comm. 93: 209-214 (1980).

38.  Thomas, D.D. and Cooke, R.  Orientation of Spin-Labelled Myosin Heads in Glycerinated Muscle Fibers.  Biophys. J. 32:891-905 (1980).

39.  Blumenthal, D.K., Stull, J.T. and Cooke, R.  Regulation of Contraction by Myosin Phosphorylation:  A Comparison Between Smooth and Skeletal Muscle.  Biochem. Pharmacol. 29:2537-2543 (1980) (Invited paper).

40.  Bardeen, J.A., Cooke, R., Wright, P.E. and dos Remedios, C.G.  Proton Nuclear Magnetic Resonance and Electron Paramagnetic Resonance Studies on Skeletal Muscle Actin Indicate that the Metal and Nucleotide-binding Sites are Separate.  Biochem. 19:5912-5916 (1980).

41.  Cooke, R., and Stull, J.T.  Myosin Phosphorylation:  A Biochemical Mechanism for Regulating Contractility, Muscle and Nonmuscle Motility, (Plenum Press) Shay and Dowben, eds. 1:99-133 (1981).

42.  Sobel, J.S., Glass, R.H., Cooke, R., Spindle, A.I., and Pedersen, R.A.  Cell Motility and the Distribution of Actin and Myosin during Mouse Trophoblast Development In Vitro.  Cellular and Molecular Aspects of Implantation, S.R. Glasser and D.W. Bullock, eds. p. 450-453 (Plenum Press) (1981).

43.  Cooke, R. Stress Does Not Alter the Conformation of a Domain of the Myosin Cross-bridge in Rigor Muscle Fibers.  Nature 294:570-571 (1981).

44.  Cooke, R.,  Fluorescence Spectroscopy as a Probe of Contraction. Methods in Enzymology 85:574-593 (1982)  (Invited paper).

45.  Morales, M.F., Borejdo, J., Botts, J., Cooke, R., Mendelson, R.A. and Takashi, R.  Some Physical Studies of the Contractile Mechanism in Muscle.  Ann. Rev. of Physical Chemistry 33:319-51 (Invited paper)  1982.

46.  Cooke, R., Franks, K. and Stull, J.T.  Myosin Phosphorylation Regulates the ATPase activity of Permeable Skeletal Muscle Fibers.  FEBS Lett. 144:33-37 (1982).

47.  Highsmith, S. and Cooke, R.  Evidence for Protein Conformation Changes Involved in Tension Generation.  Muscle and Nonmuscle Motility (Shay and Dowben, eds.) 4:207-237 (1983) (Invited paper).

48.  Heuser, J. and Cooke, R.  Actin-myosin Interaction Visualized in Freeze-Etch Replicas of S-1 Decorated Actin Filaments and Insect Flight Muscles.  J. Mol. Biol. 169:97-122 (1983).

49.  Cooke, R. Crowder, M.S. and Thomas, D.D.  Orientation of Spin Labels Attached to Cross-bridges in Contracting Muscle Fibers.  Nature 300:776-778 (1983).

50.  Fung, B.M. and Cooke, R.  Studies on the Role of the Actin Nucleotide in Contraction and Polymerization.  Actin: Structure and Function. C. G. dos Remedios and J.A. Bardeen, eds. Plenum Press (Invited paper) p.153-162 (1983).

51.  Thomas, D.D., Cooke R. and Barnett, V.A.  Orientation and Rotational Mobility of Spin-labeled Myosin Heads in Insect Flight Muscle in Rigor and Relaxation.  J. Mus. Res. and Cell Mot. 4:367-378 (1983).

52.  Cooke, R. Crowder, M.S., Wendt, C.H. and Thomas, D.D.  Muscle Cross-bridges: Do they Rotate?  Contractile Mechanisms in Muscle.  G.H. Pollack and H. Sugi, ed. (Invited paper) p. 413-427 (1984).

53.  Crowder, M.C. and Cooke, R.  The Effect of Sulphydryl Modification on the Mechanics of Fiber Contraction.  J. Mus. Res. and Cell Mot. 5:131-146 (1984).

54.  Cooke, R., Franks, K. and Stull, J.T.  Myosin Phosphorylation decreases the ATPase Activity of Cardiac Myofibrils.  J. Mol. and Cell Cardiology 16:597-604 (1984).

55.  dos Remedios, C.G. and Cooke R.  Fluorescence Energy Transfer Between Probes on Actin and Probes on Myosin.  Biochem. Biophys. Acta 788:193-205 (1984).

56.  Pate, E. and Cooke, R.  The Inhibition of Muscle Contraction by Adenosine 5' (ß imido) Triphosphate and by Pyrophosphate.  Biophys. J. 47:773-779 (1985).

57.  Persechini, A., Stull, J.T. and Cooke, R.  The Effect of Myosin Phosphorylation on the Contractile Properties of Skinned Rabbit Skeletal Muscle Fibers.  J. Biol. Chem. 260:7951-7954 (1985).

58.  Cooke, R. and Pate, E.  The Effects of ADP and Phosphate on the Contraction of Muscle Fibers.  Biophys. J., 48:789-798 (1985).

59.  Stull, J., Persechini, A., Cooke, R., Moore, L. and Nunnally, M.  Myosin Phosphorylation in Skeletal Muscle:  Regulation and Function.  Adv. Protein Phosphates II,  p. 19-36 (1985) (Invited paper).

60.  Pate, E. and Cooke, R.  A Model for the Interaction of Muscle Cross-bridges with Ligands which Compete with ADP.  J. Theo. Biol., 118:215-230 (1986).

61.  Cooke, R.  The Mechanism of Muscle Contraction.  Critical Reviews in Biochemistry, 21:53-118 (1986).

62.  Koons, S., and Cooke, R.  Function of Creatine Kinase Localization in Muscle Contraction.  Adv. Exp. Med. 194:129-137 (1986).

63.  Crowder, M.C. and Cooke, R.  The Orientation of Spin-Labelled Nucleotides Bound to Myosin in Glycerinated Muscle Fibers.  Biophys. J., 51:323-333 (1987).

64.  Waring, A.J. and Cooke, R.  The Molecular Dynamics of Actin Measured by a Spin-Probe Attached to Lysine.  Arch. Biochem. Biophys., 252:197-205 (1987).

65.  Pate, E. and Cooke, R.  Mathematical Models of Muscle Function.  IEEE/EMBS 9th Annual Conference.  Vol. I.  pp. 319-320 (1987).

66.  Cooke, R. and Pate, E.  The Effects of Pyrophosphate on Myosin Heads and on Fiber Stiffness.  Adv. in Experimental Biology 226:225-266 (1988) (Invited paper).

67.  Pate, E., Franks, K., Luciani, G. and Cooke, R.  The Inhibition of Muscle Contraction by Hydrogen Ions and Phosphate.  J. Physiol. 395:77-97 (1988).

68.  Pate, E. and Cooke, R.  The Energetics of the Actomyosin Bond in the Filament Array of Muscle Fibers.  Biophys. J. 53:561-573 (1988).

69.  Pate, E. and Cooke, R.  A Model of Cross-bridge Action: The Effects of ATP, ADP and Pi.  J. Mus. Res. Cell Mot. 10:181-196 (1989). 

70.  Pate, E. and Cooke, R.  Addition of Phosphate to Active Muscle Fibers Probes Actomyosin States within the Powerstroke.  Pflug. Arch. 414:73-81 (1989).

71.  Cooke, R.  The structure of the myosin head.  Cell Motility and the Cytoskeleton 14:183-186 (1989).

72.  Cooke, R. and Pate, E.  The Inhibition of Muscle Contraction by the Products of ATP Hydrolysis.  Biochemistry of Exercise VII  A.W. Taylor, P.D. Gollnick, H.J. Green, C.D. Ianuzzo, E.G. Noble, G. Metivier & J.R. Sutton, eds. (Human Kinetics Books, Champaign, IL) pg. 59-72 (1990).

73.  Cooke, R.  Force Generation in Muscle.  Current Opinion in Cell Biology 2:62-66 (1990).

74.  Pate, E., Franks-Skiba, K., Nakamaye, K., Cooke, R. and Yount, R.  Mechanics Of Glycerinated Muscle Fibers Using Nonnucleotide Substrates That Lack Both Ribose And Base.  Biophys. J. 59:598-605 (1991).

75.  Hambly, B.D., Franks, K. and Cooke R.  Orientation Of Spin-Labeled Light Chain-2 Exchanged Into Myosin Heads In Muscle Fibers.  Biophysical J.  59:127-138 (1991).

76.  Pate, E. and Cooke, R.  Simulation Of Stochastic Processes In Motile Cross-Bridge Systems.  J. Mus. Res. Cell Motility 12:376-393 (1991).

77.  Reedy, M.K., Nariman, N., and Cooke, R.  Insect Cross-Bridges, Relaxed By Spin-Labeled Nucleotide, Show A Well-Ordered State By X-Ray Diffraction And Electron Microscopy But Spin-Label Spectra Show Disorder. J. Mol. Biol.  227:678-697 (1991).

78.  Pate, E., Lin, M. Michael, and Cooke, R.  Contraction Of Glycerinated Rabbit Semimembranosus Fibers As A Function Of MgATP Concentration.  Am. J. Physiol., 262:C1039-C1046 (1992).

79.  Hambly, B., Franks, K. and Cooke, R.  Paramagnetic Probes Attached To A Light Chain On The Myosin Head Are Highly Disordered In Active Muscle Fibers.  Biophysical J., 63:306-1313 (1992).

80.  Pate, E., White, H. and Cooke, R.  Determination Of The Myosin Step Size From Mechanical And Kinetic Data.  Proc. Natl. Acad. Sciences. 90:2451-2455 (1993).

81.  Luo, Y.  Cooke, R. and Pate, E.  A Model Of Stress Relaxation In Cross-Bridge Systems: Effect Of A Series Elastic Element.  Am. J. Physiology 265:C279-C288 (1993).

82.  Pate, E., Franks, K., White, H. and Cooke, R.  The Use Of Differing Nucleotides To Investigate Cross-Bridge Kinetics.  J. Biol. Chem. 268:10046-10053 (1993).

83.  Cooke, R.  Sarcomeric Myosin.  Guidebook to Cytoskeletal Proteins (T. Kreis and R. Vale, eds.), pp. 207-209, Oxford University Press, Oxford, (1993).

84.  Cooke, R. The Structure Of A Molecular Motor.  Current Biol. 3:590-592 (1993).

85.  Wang, D., Pate, E., Cooke, R., and Yount, R.  Synthesis Of Non-Nucleotide ATP Analogues And Characterization Of Their Chemomechanical Interaction With Muscle Fibers.  J. Mus. Res. and Cell Motility 14:484-497 (1993).

86.  Naber, N. E. Ostap, E.M., Thomas, D.D., Cooke, R.  Orientation And Rotational Dynamics Of Spin-Labeled Phalloidin Bound To Actin In Muscle Fibers.  Proteins, Structure and Function 17:347-354  (1993).

87.  Cooke, R., White, H., Pate, E.  A Model Of The Release Of Myosin Heads From Actin In Rapidly Contracting Muscle Fibers.  Biophysical J. 66:778-788  (1994).

88.  Naber, N.I., Lorenz, M. and Cooke, R.  The Binding Of The Myosin Head Does Not Alter The Orientation Of Spin-Probes Attached To Cys 374 On Actin.  J. Mol. Biol. 236:703-709  (1994).

89.  Carreras, C.W., Naber, N., Cooke, R. and Santi, D.V.   Measurement Of The C-Terminal Conformational Change Of Thymidylate Synthase Using Electron Paramagnetic Resonance Spectroscopy.  Biochemistry 33:2017-2077  (1994).

90.  Naber, N. and Cooke, R.  Mobility And Orientation Of Spin-Probes Attached To Nucleotides Incorporated Into Actin.  Biochemistry 33:3855-3861 (1994).

91.  Pate, E., Wilson, G., Bhimani, M., and Cooke, R.  The Temperature Dependence Of The Inhibitory Effects Of Ortho Vanadate On Shortening Velocity In Chemically Skinned Fast Skeletal Muscle.  Biophys. J. 66:1554-1562 (1994).

92.  Luo, Y., Cooke, R., and Pate, E.  The Effect Of Series Elasticity On The Delay In The Development Of Tension Relative To Stiffness During Muscle Activation.  Am. J. Physiology 267:C1599-C1606 (1994).

93.  Franks-Skiba, K., Hwang, T., and Cooke, R. The Quenching Of Fluorescent Nucleotides Bound To Myosin, A Probe Of The Active Site Conformation.  Biochemistry 33:12720-12728 (1994).

94.  Luo, Y., Wang, D., Cremo, C. R., Pate, E., Cooke, R., and Yount, R. G.  Photoaffinity ADP Analogs As Covalently Attached Reporter Groups Of The Active Site Of Myosin Subfragment 1.  Biochemistry 34:1978-1987 (1994).

95.  Wilson, G. J., Shull, S. E., and Cooke, R.  Inhibition Of Muscle Force By Vanadate.  Biophys. J. 68:216-226 (1995).

96  Cooke, R.   Forward to the Seventh Biophysical Discussions - Molecular Motors - Structure, Mechanics and Energy Transduction - Airlie House, Airlie, Virginia, Biophys. J. 68:21-23s (1995).

97.  Franks-Skiba, K. and Cooke, R.  The Conformation Of The Active Site Of Myosin Probed Using Mant-Nucleotides.  Biophys. J. 68:142s-149s (1995).

98.  Pate, E., Bhimani, M., Franks-Skiba, K., and Cooke, R.  Reduced Effect Of pH On Skinned Rabbit Psoas Muscle Mechanics At High Temperatures: Implications For Fatigue.  J. Physiology 486:689-694 (1995).

99.  Zhao, L., Naber, N., and Cooke, R.  Muscle Cross-Bridges Bound To Actin Are Disordered In The Presence Of 2,3-Butanedione Monoxime.  Biophys. J. 68:1980-1990 (1995).

100.  Zhao, L., Pate, E., Baker, A. J., and Cooke, R.  The Myosin Catalytic Domain does not Rotate during the Powerstroke.  Biophys. J. 69:994-999 (1995).

101.  Cooke, R. The Actomyosin Engine. FASEB Journal 9:636-642  (1995).

102.  Naber, N., Matuska, M., Sablin, E. P., Pate, E. and Cooke, R.  A Novel Adenosine Triphosphate Analog with a Heavy Atom to Target the Nucleotide Binding Site of Proteins.  Protein Science 4:1824-1831  (1995).

103.  Myburgh, K. H., Franks-Skiba, K., and Cooke, R.  Nucleotide Turnover Rate Measured In Fully Relaxed Rabbit Skeletal Muscle Myofibrils.  J. Gen. Physiol. 106:957-973  (1995).

104.  Quan, D., Cooke, R.A., and Maibach, H.I.  An Electron Spin Resonance Study Of Human Epidermal Lipids Using 5-Doxyl Stearic Acid.  J. Controlled Rls. 26:235-241  (1995).

105.  Highsmith, S., Duignan, K., Cooke, R., and Cohen, J.,  Osmotic Pressure Probe of Actin-Myosin Hydration Changes During ATP Hydrolysis.  Biophys J. 70:2830-2837 (1996).

106.  Sablin, E.P., Kull, F.J., Cooke, R., Vale, R.D., and Fletterick, R.J.  Three-Dimensional Structure of the Motor Domain of NCD, a Kinesin-Related Motor with Reversed Polarity of Movement.  Nature 380:555-559 (1996).

107.  Zhao, L., Gollub, J., and Cooke, R.  Orientation of Paramagnetic Probes Attached to Gizzard Light Chain-2 Bound to Myosin Heads in Rabbit Skeletal Muscle.  Biochemistry 35:10158-10165 (1996).

108.  Gollub, J., Cremo, C.R., and Cooke, R.  ADP Release Produces A Rotation Of The Neck Region Of Smooth Myosin But Not Skeletal Myosin.  Nature Structural Biology 3:796-802 (1996).

109.  Cuda, G., Pate, E., Cooke, R., and Sellers, J.  In Vitro Actin Filament Sliding Velocities Produced By Mixtures Of Different Types Of Myosin.  Biophysical J.  72:1767-1779 (1997).

110.  Myburgh, K. and Cooke, R.  The Response Of Compressed Skinned Skeletal Muscle Fibers To Conditions That Simulate Fatigue.  J. Applied Physiol. 82:1297-1304 (1997).

111. Cooke, R.  The Actomyosin Interaction in Striated Muscle.  Physiological Rev.  77: 671-697 (1997).

112.  Naber, N., Cooke, R., Pate, E.  Binding of ncd To Microtubules Induces a Conformational Change Near the Junction of the Motor Domain with the Neck  Biochemistry 36: 9681-9689 (1997).

113.  Pate, E., Naber, N., Matuska, M., Franks-Skiba, K., and Cooke, R.  Opening of the Myosin Nucleotide Triphosphate Binding Domain During the ATPase Cycle.  Biochemistry 36  (1997).

114.  Wilson, J.G., Shull, S.E., Naber, N.I., and Cooke, R.  Myosin Heads Interactions In Ca2+-Activated Skinned Rabbit Skeletal Muscle Fibers.  J. Biochem. 122:563-571 (1997).

115.  Cooke, R.  New Angle On Myosin.  Proc. Nat. Acad. Sci. 95:2720-2722 (1998). 

116.  Highsmith, S., Duignan, K., Franks-Skiba, K., Polosukhina, K., Cooke, R.  Reversible Inactivation Of Myosin Subfragment 1 Activity By Mechanical Immobilization.  Biophysical J. 74:1465-1472 (1998).

117.  Pate, E., Franks-Skiba, K., Cooke, R.  Depletion Of Phosphate In Active Muscle Probes Actomyosin States Within The Powerstroke.  Biophysical J. 74:369-380 (1998). 

118.  Selvin, P., Burmeister-Getz, E., Cooke, R.  Luminescence Resonance Energy Transfer Measurements on the Post-Power Stroke of Actomyosin.  Biophysical J. 74:2451-2458 (1998). 

119.  Burmeister-Getz, E., Cooke, R., and Lehman S.  Phase Transition In Force During Ramp Stretches Of Skeletal Muscle.  Biophysical J. 75:2971-2983 (1998).

120.  Xiao, M., Li, H., Snyder, G., Cooke, R., Yount, R. Selvin, P.  Conformational Changes Between The Active-Site And Regulatory Light Chain Of Myosin As Determined By Luminescence Resonance Energy Transfer:  The Effect Of Nucleotides And Actin.  Proc. Nat. Acad. Sci. 95:15309-15314 (1999).

121.  Cooke, R.  A Fidgeter's Calculation.  Science 284:1125-1126 (1999).

122.  Gollub, J., Cremo, C.R. and Cooke, R. The ADP-Induced Rotation Of The Light Chain Domain Of Smooth Muscle Myosin Is Regulated By Myosin Phosphorylation.  Biochemistry 38:10107-10118 (1999). 

123.  Burmeister-Getz, E., Xiao, M., Chakrabarty, T., Cooke, R., Selvin, P.  A Comparison Between The Sulfhydryl Reductants Tris(2-Carboxyethyl) Phosphine And Dithiothreitol For Use In Protein Biochemistry.    Anal. Biochem. 273:73-80 (1999).

124.  Kawasaki, Y., Quan, D., Sakamoto, K., Cooke, R., Maibach, H.  Influence Of Surfactants Mixture In Intercellular Lipid Fluidity And Skin Barrier Function.  Skin Research and Technology 5:96-101 (1999).

125.  Wang, D., Luo, Y., Cooke, R., Pate, E., Yount, R.G.  Synthesis Of A Spin-Labeled Photoaffinity ATP Analog And Its Use To Specifically Photolabel Myosin Cross-Bridges In Skeletal Muscle Fibers.  J. Mus. Res. and Cell Motility  20:743-753 (1999).

126. Rice, S., Lin, A.W., Safer, D., Hart, C.L., Naber, N., Carragher, B.O., Cain, S.M., Pechatnikova, E., Wilson-Kubalek, E.M., Whittaker, M., Pate, E., Cooke, R., Taylor, E.W., Milligan, R.A., and Vale, R.D.    A Structural Change in the Kinesin Motor Protein that Drives Motility.   Nature  402:778-784  (1999).

127. Cooke, R.   Myosin structure: does the tail wag the dog?  Current Biology, 9:R773-5 (1999).

128. Cooke, R.  Sarcomeric Myosin.  in Guidebook to theCytoskeletal and Motor Proteins  2nd Edition (T. Kreis and R. Vale, eds.), pp. 421-425, Oxford University Press, Oxford (1999). 

129. Thorn, K.S., Naber, N., Matuska, M., Vale, R.D., and Cooke, R.  A Novel Method of Affinity-Purifying Proteins Using a bis-Arsenical Fluorescein.  Protein Science,  9:1-5 (2000). 

130. Chinn, M. K., Myburgh, K. H., Pham, T , Franks-Skiba, K., and Cooke, R. The Effect Of Polyethylene Glycol On The Mechanics And ATPase Activity Of Active Muscle Fibers. Biophys. J.  78:  927-939   (2000).

131. Cooke, R .,  Motor Proteins, in Embryonic Encyclopedia of Life Sciences, Nature Publishing Group, London: http://www.els.net. (May 2000).

132. Mizushima, J., Kawasaki, Y., Tabohashi, T., Kitano, T., Sakamoto, K., Kawashima, M., Cooke, R., and Maibach, H.I. Effect of Surfactants on Human Stratum Corneum: Electron Paramagnetic Resonance Study.  Int. J. Pharmacology,  197:  193-202 (2000). 

133.  Chen, X., Grammer, J., Cooke, R., Pate, E., and Yount , R. G., Synthesis and Characterization of Novel Spin-Labeled Photoaffinity Nonnucleoside Analogs of ATP as Structural and EPR Probes for Myosin.  Biocongugate Chemistry, 11:725-733 (2000).

134. Mizushima, J; Kawasaki, Y; Sakamoto, K; Kawashima, M; Kawashima, M., Cooke, R., and Maibach, H.I. Electron paramagnetic resonance: a new technique in skin research.  Skin Research And Technology,  6:100-107 (2000).

135.  Minehardt, T.J., Cooke, R., Pate, E., Kollman, P.A. Molecular dynamics study of the energetic, mechanistic, and structural implications of a closed phosphate tube in ncd. Biophysical Journal, 80:1151-1168 (2001).

136.  Minehardt, T.J., Marzari, N., Cooke, R., Pate, E., Kollman, P.A., and Car, R. 
A classical and ab initio study of the interaction of the myosin triphosphate binding domain with ATP.  Biophys. J. 82:660-675 (2002).

137. Chakrabarty, T., Xiao, M.,  Cooke, R., Selvin, P.R.  Holding two heads together:  stability of the myosin II rod measured by resonance energy transfer.  Proc. National Academy of Sciences  999:6011-6016  (2002).

138. Sindelar, C.V., Rice, S., Budny, M.J., Fletterick, R.J., and Cooke, R.  Two Conformations in the Human Kinesin Powerstroke Defined by X-ray Crystallography and EPR spectroscopy.  Nature Structural biology, 11:844-848 (2002).

139. Chen, X., Grammer, J., Lawson, J.D., Cooke, R., Pate, E., Yount, R.G.  A novel restricted photoaffinity spin-labeled non-nucleoside ATP analogue as a covalently attached reporter group of the active site of Myosin subfragment 1.  Biochemistry, 41:2609-2620 (2002).

140. Cooke, R.  Do Longer Oars Row Farther? Mol Cell 10:966-7 (2002).

141. Rice, S., Cui, Y., Sindelar, C., Naber, N., Matuska, M., Vale, R., Cooke, R. Thermodynamic Properties of the Kinesin Neck Region Docking to the Catalytic Core Biophysical Journal, 84:1844-1854 (2003).

142. Karatzaferi, C., Myburgh K.H., Chinn, M.C., Franks-Skiba, K., and Cooke, R. The Effect Of An ADP Analog On Isometric Force And ATPase Activity Of Active Muscle Fibers.  Am. J. Physiology, 284: C816-825 (2003).

143. Naber, N., Rice, S., Matuska, M., Vale, R.D., Pate, E., and Cooke, R.  EPR spectroscopy shows a microtubule-dependent conformational change in the switch 1 domain of kinesin.  Biophysical J. 84:3190-3196 (2003).

144. Naber, N., Minehardt, T.J., Rice, S., Chen, X., Grammer, J., Matuska, M., Car, R.,  Vale, R.D., Kollman, P.A., Yount, R.G., Cooke, R., and Pate, E..  The nucleotide pocket of kinesin-family motors closes upon binding to microtubules Science 300: 798-801 (2003).

145. Chinn, M., Burmeister-Getz, E., Cooke, R., and Lehman, S.L. Force Enhancement by PEG During Ramp Stretches of Skeletal Muscle. J. Muscle Research And Cell Motility 24(8):571-8 (2003).

146. Tanaka, M., Chien, P., Naber, N., Cooke, R., Weisman, J. Conformational Variations in an Infectious Protein Determine Prion Strain Differences. Nature, 428(6980):323-8..(2004)

147.  Karatzaferi C., Chinn, M.K., and Cooke, R.  The Force Exerted By A Muscle Crossbridge Depends Directly On The Strength Of the Actomyosin Bond. Biophysical J. 87: 2532-2544 (2004)

148,  Cooke, R. The Sliding Filament Model:  1972-2004. J. Gen. Physiol. 123:643–656 (2004)

149.  Vinogradova, M. V., Stone, D. B., Malanina, G. G., Karatzaferi, C., Cooke, R., Mendelson R., Fletterick R. J., How troponin works and how it can be regulated.  Proc. Nat. Acad. Sci. 102(14):5038-43 (2005).

150.    Minehardt, T.J., Kollman P.A., Cooke, R., and Pate, E, The open nucleotide pocket of the profilin/actin x-ray structure is unstable and closes in the absence of profilin. Biophys J. 90:2445-9 (2006). 

*151.  Naber, N. , Purcell, T., Pate, E., and Cooke, R.    Dynamics Of The Nucleotide Pocket Of Myosin Measured By Spin-Labeled Nucleotides.  Biophys. J. 92:172-184 (2007). 

152.  Franks-Skiba, K., Lardelli, R., Goh, G., and Cooke, R.    Myosin Light Chain Phosphorylation Inhibits Muscle Affects Fiber Shortening Velocity In The Presence Of Vanadate.  Am. J. Physiology 292:R1603-12. (2007). 

153.  Cooke R.    Modulation Of The Actomyosin Interaction During Fatigue Of Skeletal Muscle.   Muscle Nerve. 36(6):756-77 (2007).  

154.   Karatzaferi, C. Franks-Skiba, K., Cooke, R.    The Inhibition Of Shortening Velocity Of Skinned Skeletal Muscle Fibers In Conditions That Mimic Fatigue.  Am J. Physiol Regul Integr Comp Physiol. 294:948-955 (2008). 

155. Thompson, A.R., Naber, N., Wilson, C., Cooke, R., and Thomas, D. D. Structural Dynamics Of The Actomyosin Complex Probed By A Bifunctional Spin Label That Crosslinks SH1 and SH2 Biophysical J. 95:52238-5246 (2008)

156. Stewart, M., Franks-Skiba, K., and Cooke, R. Myosin Light Chain Phosphorylation Inhibits Shortening Velocities In Skeletal Muscle Fibers In The Presence Of The Myosin Inhibitor Blebbistatin J. Muscle Res. Cell Motil., 30:17-27 (2009)

157. Wong*, Y.L., Dietrich*, K.A., Naber, N., Cooke R., and Rice, S.E. The Kinesin-1 Tail Conformationally Restricts the Nucleotide Pocket. Biophysical J. 96:2799-2807 (2009)

158. Iwaki, M., Iwane, A., Cooke, R., Yanagida, T. Brownian Search and Catch Mechanism for Myosin-VI Steps. Nature Chemical Biology 5:403 - 405 (2009)

159. Hyatt, H., Cooke, R., and Pate*, E. Analysis of the Interaction of the Nucleotide Base with Myosin and the Effect on Substrate Efficacy. Biophys J. 97:1952-60. (2009)

160. Lisa R. Racki, Janet G. Yang, Nariman Naber, Peretz Partensky, Ashley Acevedo, Tom J. Purcell, Roger Cooke, Yifan Cheng, & Geeta J. Narlikar. The chromatin-remodeling complex ACF functions as a dimeric motor to space nucleosomes, Nature. 462:1016-21. (2009)

161. Naber N., Málnási-Csizmadia A., Purcell T.J., Cooke R., and Pate E. Combining EPR with Fluorescence Spectroscopy to Monitor Conformational Changes at the Myosin Nucleotide Pocket. J Mol Biol. 2010 396:937-48 (2009).

162. Stewart M., Franks-Skiba K., Chen S. and Cooke R. Myosin ATP Turnover Rate is a Mechanism Involved In Thermogenesis in Resting Skeletal Muscle Fibers. Proc Natl Acad Sci U S A. 107:430-5 (2010)

163. Larson, A, G., Naber, N., Cooke, R, Pate, E. and Rice, S. E., A Conserved Element In Kinesin-5 Motors Couples ADP Release To A Forward Step, Biophys J. 98:2619-27. (2010).

164. Purcell, T., Naber, N. Franks-Skiba, K., Dunn, R. A., Eldred, C. C., Berger, C. L. ,  Málnási-Csizmadia, A. Spudich, J. A. Swank, D. M.  Pate, E., and Cooke, R. Nucleotide Pocket Thermodynamics Measured by EPR Reveal How Energy Partitioning Relates Speed to Efficiency. J Mol Biol. 407(1):79-91 (2011) PMID: 21185304

165.  Cooke, R. The Role of the Myosin ATPase Activity in Adaptive Thermogenesis by Skeletal Muscle.  In Press   Biophysical Reviews, (2011)

166.  Naber, N., Larson, A., Rice, S., Cooke, R., and Pate, E., Multiple Conformations of the Nucleotide Site of Kinesin Family Motors in the Triphosphate State., J Mol Biol. 2011. [Epub ahead of print].  PMID: 21277856

167.  Hooijman, P., Stewart, M. A., and Cooke, R.   A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardio-Protective Mechanism In The Heart.   Biophys. J. (in press)
 

168. Naber, N., Cooke, R., and Pate, E. Slow Myosin ATP Turnover In The Super-Relaxed State In Tarantula Muscle. J. Mol. Biol. 411:943-950 (2011) PMID:1763701

169. Harrington, T.D., Naber, N., Larson, A. G., Cooke, R., Rice, S. and Pate, E. Analysis Of The Interaction Of The Eg Loop5 With The Nucleotide Site. J. Theoretical Biology 289: 107-115 (2011) PMID: 21872609

170. Waitzman J.S., Larson A.G., Cochran J.C., Naber N., Cooke R., Kull J.F., Pate E., Rice S.E. The loop 5 element structurally and kinetically coordinates dimers of the human Kinesin-5, eg5. Biophys J. 101:2760-2769 (2011) PMID: 22261065

171 Purcell, T. J., Naber N., Sutton S., Cooke R., Pate E. EPR spectra and molecular dynamics agree that the nucleotide pocket of myosin V is closed and that it opens on binding actin. J. Mol. Biol. 411:16-26. (2011) PMID: 21640122

172. Foreman AL, Phillips L, Kanellis VG, Hammoudeh D, Naumann C, Wong H, Chisari R, Hibbert DB, Lee GS, Patra R, Julli M, Chapman J, Cooke AR, dos Remedios CG A DNA-based assay for toxic chemicals in wastewater. Environ Toxicol Chem. 30:1810-8 (2011) PMID: 21560144

173. Canzio, D., Liao, M., Naber, N., Pate, E., Larson, A., Wu, S., Cooke, R., Schuck, P., Cheng, Y., Narlikar, G. J. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 496:377-81 (2013) PMID:23485968

174. Eldred, C. C., Naber, N., Pate, E., Cooke, R., Swank, D M. Conformational Changes At The Nucleotide Site In The Presence Of Bound ADP Do Not Set The Velocity Of Fast Drosophila Myosins. J. Musc. Res. Cell Motil. 34:35-42. (2013) PMID: 23203294

175. Racki, L. R. , Naber, N. Pate, E. Leonard, J. Cooke, R., Narlikar, G. J. The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme. J Mol Biol. 426:2034-44. (2014) PMID:24607692

176. Wilson, C., Naber, N. Pate, E., Cooke, R. The Myosin Inhibitor Blebbistatin Stabilizes The Super-Relaxed State In Skeletal Muscle, Biophys J. 107:1637-46. (2014) PMID:25296316

177. Partridge JR, Lavery LA, Elnatan D, Naber N, Cooke R, Agard DA. A novel N- terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity. Elife. Dec 22;3. doi: 10.7554/eLife.03487. (2014) PMID:25531069

178. McNamara, JW, Li, A, dos Remedios, CG, Cooke, R The role of super-relaxed myosin in skeletal and cardiac muscle Biophys Rev 7:5–14 (2015)

179. Lal S, Li A, Allen D, Allen PD, Bannon P, Cartmill T, Cooke R, Farnsworth A, Keogh A, Dos Remedios C. Best Practice BioBanking of Human Heart Tissue. Biophys Rev. 2015 Dec;7(4):399-406. Epub 2015 Nov 2. PMID:26998172

180. McNamara JW, Li A, Smith NJ, Lal S, Graham RM, Kooiker KB, van Dijk SJ, Remedios CG, Harris SP, Cooke R. Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. J Mol Cell Cardiol. 2016 May;94:65-71. doi: 10.1016/j.yjmcc.2016.03.009. Epub 2016 Mar 26. PMID:27021517

181. Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R. Spectroscopic Studies of the Super Relaxed State of Skeletal Muscle. PLoS One. 2016 Aug 1;11(8):e0160100. doi: 10.1371/journal.pone.0160100 PMID:27479128

182. Nogara L, Naber N, Pate E, Canton M, Reggiani C, Cooke R. Piperine’s mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle. Proc Natl Acad Sci USA, in press.