Journal of the American Chemical Society

Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network.

Journal of the American Chemical Society

Hu S, Offenbacher AR, Thompson EM, Gee CL, Wilcoxen J, Carr CAM, Prigozhin DM, Yang V, Alber T, Britt RD, Fraser JS, Klinman JP

Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.

Journal of the American Chemical Society

Li X, Sevillano N, La Greca F, Deis L, Liu YC, Deller MC, Mathews II, Matsui T, Cane DE, Craik CS, Khosla C

Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases.

Journal of the American Chemical Society

Acker TM, Gable JE, Bohn MF, Jaishankar P, Thompson MC, Fraser JS, Renslo AR, Craik CS

Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases.

Journal of the American Chemical Society

Acker TM, Gable JE, Bohn MF, Jaishankar P, Thompson MC, Fraser JS, Renslo AR, Craik CS

Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology.

Journal of the American Chemical Society

Lopez MS, Choy JW, Peters U, Sos ML, Morgan DO, Shokat KM

The role of ligands on the equilibria between functional states of a G protein-coupled receptor.

Journal of the American Chemical Society

Kim TH, Chung KY, Manglik A, Hansen AL, Dror RO, Mildorf TJ, Shaw DE, Kobilka BK, Prosser RS

Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.

Journal of the American Chemical Society

Wang Z, Sapienza PJ, Abeysinghe T, Luzum C, Lee AL, Finer-Moore JS, Stroud RM, Kohen A

Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.

Journal of the American Chemical Society

Wang Z, Sapienza PJ, Abeysinghe T, Luzum C, Lee AL, Finer-Moore JS, Stroud RM, Kohen A

A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase.

Journal of the American Chemical Society

Wang Z, Abeysinghe T, Finer-Moore JS, Stroud RM, Kohen A

A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase.

Journal of the American Chemical Society

Wang Z, Abeysinghe T, Finer-Moore JS, Stroud RM, Kohen A

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