Journal of the American Chemical Society

Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.

Journal of the American Chemical Society

Wang Z, Sapienza PJ, Abeysinghe T, Luzum C, Lee AL, Finer-Moore JS, Stroud RM, Kohen A

Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.

Journal of the American Chemical Society

Wang Z, Sapienza PJ, Abeysinghe T, Luzum C, Lee AL, Finer-Moore JS, Stroud RM, Kohen A

A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase.

Journal of the American Chemical Society

Wang Z, Abeysinghe T, Finer-Moore JS, Stroud RM, Kohen A

A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase.

Journal of the American Chemical Society

Wang Z, Abeysinghe T, Finer-Moore JS, Stroud RM, Kohen A

Tuning a three-component reaction for trapping kinase substrate complexes.

Journal of the American Chemical Society

Statsuk AV, Maly DJ, Seeliger MA, Fabian MA, Biggs WH, Lockhart DJ, Zarrinkar PP, Kuriyan J, Shokat KM

Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine.

Journal of the American Chemical Society

Lampe JN, Floor SN, Gross JD, Nishida CR, Jiang Y, Trnka MJ, Ortiz de Montellano PR

Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine.

Journal of the American Chemical Society

Lampe JN, Floor SN, Gross JD, Nishida CR, Jiang Y, Trnka MJ, Ortiz de Montellano PR

A remodelled protease that cleaves phosphotyrosine substrates.

Journal of the American Chemical Society

Knight ZA, Garrison JL, Chan K, King DS, Shokat KM

Engineering modular protein interaction switches by sequence overlap.

Journal of the American Chemical Society

Sallee NA, Yeh BJ, Lim WA

Engineering modular protein interaction switches by sequence overlap.

Journal of the American Chemical Society

Sallee NA, Yeh BJ, Lim WA

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