eLife

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.

eLife

Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.

eLife

Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P

A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity.

eLife

Partridge JR, Lavery LA, Elnatan D, Naber N, Cooke R, Agard DA

Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy.

eLife

Warkentin AA, Lopez MS, Lasater EA, Lin K, He BL, Leung AY, Smith CC, Shah NP, Shokat KM

A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells.

eLife

Erb ML, Kraemer JA, Coker JK, Chaikeeratisak V, Nonejuie P, Agard DA, Pogliano J

Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity.

eLife

Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat KM, Ibanez CF

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